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First published online February 4, 2005
Journal of Experimental Biology 208, 681-686 (2005)
Published by The Company of Biologists 2005
doi: 10.1242/jeb.01436

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Intracellular calcium and survival of tadpole forebrain cells in anoxia

Michael S. Hedrick^1,2,*, Christian S. Fahlman¹ and Philip E. Bickler¹

¹ Department of Anesthesia, University of California, San Francisco, CA 94143-0542, USA
² Department of Biological Sciences, California State University, Hayward, Hayward, CA 94542-3083, USA

View larger version (10K): [in a new window]   Fig. 1. Percentage of live cells exposed to normoxic and anoxic conditions. Cell death was determined by PI uptake following exposure to normoxia, 1 h anoxia, 4-6 h anoxia, 4-6 h anoxia followed by reoxygenation for 18 h (re-oxy), 18 h anoxia and 18 h normoxic control (cont). Values are means ± S.E.M. *P<0.05 compared with control.

View larger version (9K): [in a new window]   Fig. 2. Intracellular calcium ([Ca2+]i) (nmol l-1) measured with fura-2. Measurements were taken from tadpole forebrain cells after exposure to normoxia and 1-6 h anoxia. Values are means ± S.E.M., N=13-65 cells; *P<0.05 from normoxia.

View larger version (11K): [in a new window]   Fig. 3. Intracellular calcium [Ca2+]i (nmol l-1) measured with fura-2FF. Measurements were taken from forebrain cells after exposure to normoxia, and 1-4 h anoxia and 4 h normoxic control. Values are means ± S.E.M., N=21-172 cells; *P<0.05, **P<0.01 from normoxia or control.

View larger version (12K): [in a new window]   Fig. 4. Intracellular calcium [Ca2+]i (nmol l-1) measured with BTC. Measurements were taken from forebrain cells after exposure to normoxia, and 1-4 h anoxia and 4 h normoxic control. Values are means ± S.E.M., N=12-36 cells; *P<0.01 from normoxia or control.