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First published online September 16, 2005
Journal of Experimental Biology 208, 3739-3746 (2005)
Published by The Company of Biologists 2005
doi: 10.1242/jeb.01834

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Endothelin-1 causes systemic vasodilatation in anaesthetised turtles (Trachemys scripta) through activation of ET_B-receptors

Nini Skovgaard^1,*, Daniel E. Warren^1,2, Donald C. Jackson² and Tobias Wang¹

¹ Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, Denmark
² Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, RI 02912, USA

View larger version (19K): [in a new window]   Fig. 1. Original recordings from one turtle (Trachemys scripta) showing changes in the recorded variables following injection of ET-1 (120 pmol kg-1) and ETB-agonist (150 pmol kg-1). Arrows indicate the time of injection. Psys, systemic arterial pressure; LAo, left aortic blood flow; Ppul, pulmonary arterial pressure; LPA, left pulmonary blood flow.

View larger version (24K): [in a new window]   Fig. 2. Effects of bolus intra-arterial injections of ET-1 on the maximum change in mean arterial systemic and pulmonary pressures, (A) Psys and (D) Ppul, respectively; systemic and pulmonary blood flows, (B) sys and (E) pul; systemic and pulmonary vascular conductances, (C) Gsys and (F) Gpul as a function of the amount of peptide injected. Data points show means ± S.E.M. for eight (systemic variables) and six (pulmonary variables) individual experiments. The asterisks denote a significant difference (P<0.05) from the pre-injection value.

View larger version (26K): [in a new window]   Fig. 3. Effects of bolus intra-arterial injections of ET-1 on the maximum change in (A) total cardiac output (tot), (B) heart rate (fH), (C) total stroke volume (VStot) and (D) pul/sys as a function of the amount of peptide injected. Data points show means ± S.E.M. for seven individual experiments. The asterisks denote a significant difference (P<0.05) from the pre-injection value.

View larger version (25K): [in a new window]   Fig. 4. Effects of bolus injections of ET-1 (120 pmol kg-1) before pharmacological manipulation and after infusion of ETB-antagonist (0.15 µmol kg-1) and tezosentan (15.4 µmol kg-1) on relative changes in haemodynamic variables. Data points show means ± S.E.M. for five individual experiments. Bars marked with different letters are significantly different from each other (P<0.05).