spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Summary Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cowan, K. J.
Right arrow Articles by Storey, K. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cowan, K. J.
Right arrow Articles by Storey, K. B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress

Kyra J. Cowan1 and Kenneth B. Storey2,*

1 Department of Surgery, Surgical Research Laboratory, San Francisco General Hospital and University of California, San Francisco, San Francisco, California 94110, USA
2 Institute of Biochemistry, College of Natural Sciences, Carleton University, Ottawa, Ontario, Canada K1S 5B6



View larger version (17K):

[in a new window]
  		Fig. 1. Flow chart of the three MAPK modules (ERKs, JNKs, p38), showing stimuli, the three-tier regulatory cascade within each module (MAPK, MAPKK and MAPKKK levels) and the various cellular responses elicited by MAPK control.

 


View larger version (34K):

[in a new window]
  		Fig. 2. MAPK responses in stress-tolerant animals. (A) JNK activity in organs from control (C) and anoxia-exposed (1, 5 and 20 h anoxic submergence at 5°C) hatchling turtles Trachemys scripta elegans. Left, representative autoradiograms of phosphorylated 32P-c-Jun-GST; right densitometry results (means ± S.E.M.) for N=3 trials. (B) Amount of phosphorylated (active) p38 in organs from control (C) versus frozen (20 min, 1 and 12 h at –2.5°C) wood frogs Rana sylvatica. On the left are representative western blots using antibody to the phosphorylated (tyr 182) peptide; on the right are densitometry results, means ± S.E.M., N=3. *Significantly different from the corresponding control value, P<0.05. From Greenway and Storey (1999Go, 2000aGo).

 


View larger version (35K):

[in a new window]
  		Fig. 3. Summary of MAPK signaling pathways, showing cross-talk between modules.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



© The Company of Biologists Ltd 2003