spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 23, 2003
This Article
Right arrow Summary Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JEB
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borovsky, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borovsky, D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Trypsin-modulating oostatic factor: a potential new larvicide for mosquito control

D. Borovsky

University of Florida-IFAS, Florida Medical Entomology Laboratory, 200 9th Street, SE Vero Beach, FL 332962,



View larger version (49K):

[in a new window]
  		Fig. 1. A three-dimensional NMR model of Aedes aegypti trypsin-modulating oostatic factor (Aea-TMOF). A left-handed helix of six prolines can be observed at the C-terminus. The N-terminus with the first four amino acid sequence (YDPA) that is important in binding to the TMOF gut receptor is underlined.

 


View larger version (121K):

[in a new window]
  		Fig. 2. Immunolocalization of trypsin-modulating oostatic factor (TMOF) binding to mosquito midgut receptor 48 h after the blood meal. (A) A transverse section (7 µm) was incubated with TMOF and polyclonal antibodies. Distinct binding of TMOF to its receptor was observed on a small area of the transverse section (dark area between arrows). (B). Fourfold magnification of the binding region. PM, peritrophic membrane; Lu, gut lumen; He, hemolymph side of the gut.

 


View larger version (50K):

[in a new window]
  		Fig. 3. Effect of feeding Aedes aegypti trypsin-modulating oostatic factor (Aea-TMOF) on larval growth and development. Mosquito larvae were fed Brewer's yeast (20 µg) with either (A) 188 µg TMOF or (B) no TMOF. Larval growth and development were compared after 6 days.

 

Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?



© The Company of Biologists Ltd 2003