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Maintaining muscle mass during extended disuse: aestivating frogs as a model species

Nicholas J. Hudson and Craig E. Franklin^*

Physiological Ecology Laboratory, Department of Zoology and Entomology, The University of Queensland, Brisbane, QLD 4072, Australia

View larger version (13K): [in a new window]   Fig. 1. The relationship between body-mass-specific metabolic rate and percentage muscle disuse atrophy (normalised to 12 days) for mammals with hindlimbs artificially immobilised (r2=0.76, P<0.01).

View larger version (28K): [in a new window]   Fig. 2. A schematic diagram showing factors contributing to the rate of muscle atrophy resulting from prolonged inactivity or limb immobilisation. ROS, reactive oxygen species.

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