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Mitochondrial ATP-sensitive K⁺ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart

Tyson J. MacCormack and William R. Driedzic^*

Ocean Sciences Centre, Memorial University of Newfoundland, St John's, Newfoundland, Canada AlC 5S7

View larger version (34K): [in a new window]   Fig. 1. Twitch force and resting tension for ventricular preparations from yellowtail flounder (A) and Atlantic cod (B) exposed to oxygenated conditions () (flounder, N=6; cod, N=5) and to 35 min of anoxia followed by reoxygenation ([UNK]) (N=10, for both species). Arrows indicate times at which anoxia was induced (N2) (20 min) and when preparations were reoxygenated (O2) (55 min). `a' indicates significant difference between treatments. `b' indicates a significant decrease or increase from measurements within the treatment taken 5 min beforehand.

View larger version (26K): [in a new window]   Fig. 2 . Twitch force and resting tension for ventricular preparations from yellowtail flounder subjected to anoxia and reoxygenation and treated with agents to affect KATP-channel activity. Arrows indicate times at which anoxia was induced (20 min) and when preparations were reoxygenated (55 min). (A) DMSO treated (diamonds) (N=13). (B) Glibenclamide-treated (squares) (N=8). Inset graph shows change in twitch force associated with glibenclamide treatment against time (% force from glibenclamide-treated preparations — % force from DMSO-treated preparations). (C) Diazoxide treated (hexagons) (N=5). Inset graph shows alterations in twitch force associated with diazoxide treatment against time (% force from diazoxide-treated preparations — % force from DMSO-treated preparations). (D) 5HD-treated (triangles) (N=6). Inset graph shows alterations in twitch force associated with 5HD treatment against time (% force from 5HD treated preparations — % force from untreated preparations). `a' indicates significant difference between pharmacological treatment and appropriate control. `b' indicates a significant change from measurements within the treatment taken 5 min beforehand.

View larger version (26K): [in a new window]   Fig. 3 . Twitch force and resting tension for ventricular preparations from Atlantic cod subjected to anoxia and reoxygenation, and treated with agents to affect KATP-channel activity. Arrows indicate times at which anoxia was induced (20 min) and when preparations were reoxygenated (55 min). (A) DMSO treated (diamonds) (N=13). (B) Glibenclamide-treated (squares) (N=8). (C) Diazoxide treated (hexagons) (N=5). (D) 5HD-treated (triangles) (N=5). `b' indicates a significant change from measurements within the treatment taken 5 min beforehand.