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Journal of Experimental Biology, Vol 97, Issue 1 121-136, Copyright © 1982 by Company of Biologists
JOURNAL ARTICLES |
WR Taylor, JC Dunlap and JW Hastings
One-hour pulses of anisomycin (0.3 microM), streptimidone (30 microM) and cycloheximide (5 microM) caused strong phase-shifts (either advances or delays, of up to 12 h) in the circadian rhythm of the bioluminescence glow in the marine photosynthetic dinoflagellate, Gonyaulax polyedra. Similar pulses of emetine (0.1-100 microM) caused small (less than 4 h) phase shifts. Drug pulses have quantitatively different effects when applied at different phases of the circadian cycle, thus giving rise to 'phase response curves' (PRC's). The results lend additional support to the generalization, based on results from several different organisms, that 80s ribosome protein synthesizing system is of key importance in the mechanism responsible for circadian rhythms.
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  T. H. Davis Profile of J. Woodland Hastings PNAS, January 16, 2007; 104(3): 693 - 695. [Full Text] [PDF]
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 I. W. Jolma, G. Falkeid, M. Bamerni, and P. Ruoff Lithium Leads to an Increased FRQ Protein Stability and to a Partial Loss of Temperature Compensation in the Neurospora Circadian Clock. J Biol Rhythms, October 1, 2006; 21(5): 327 - 334. [Abstract] [PDF]
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T. Roenneberg and W. Taylor Light-Induced Phase Responses in Gonyaulax Are Drastically Altered by Creatine J Biol Rhythms, March 1, 1994; 9(1): 1 - 12. [Abstract] [PDF]
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J. Comolli, W. Taylor, and J.W. Hastings An Inhibitor of Protein Phosphorylation Stops the Circadian Oscillator and Blocks Light-Induced Phase Shifting in Gonyaulax polyedra J Biol Rhythms, March 1, 1994; 9(1): 13 - 26. [Abstract] [PDF]
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H. Broda, C. H. Johnson, W. R. Taylor, and J.W. Hastings Temperature Dependence of Phase Response Curves for Drug-Induced Phase Shifts J Biol Rhythms, September 1, 1989; 4(3): 327 - 333. [Abstract] [PDF]
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S.J. Yeung and A. Eskin Responses of the Circadian System in the Aplysia Eye to Inhibitors of Protein Synthesis J Biol Rhythms, September 1, 1988; 3(3): 225 - 236. [Abstract] [PDF]
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K. Homma and J. W. Hastings Cell Cycle Synchronization of Gonyaulax polyedra by Filtration: Quantized Generation Times J Biol Rhythms, March 1, 1988; 3(1): 49 - 58. [Abstract] [PDF]
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W. Olesiak, A. Ungar, C. H. Johnson, and J. W. Hastings Are Protein Synthesis Inhibition and Phase Shifting of the Circadian Clock in Gonyaulax Correlated? J Biol Rhythms, June 1, 1987; 2(2): 121 - 138. [Abstract] [PDF]
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 F. Sulzman, D Ellman, C. Fuller, M. Moore-Ede, and G Wassmer Neurospora circadian rhythms in space: a reexamination of the endogenous-exogenous question Science, July 13, 1984; 225(4658): 232 - 234. [Abstract] [PDF]
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