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Journal of Experimental Biology 89,177-192 (1980)
Published by Company of Biologists 1980

Feed-back Modulation of Cone Synapses by L-Horizontal Cells of Turtle Retina

H. M. GERSCHENFELD ¹, M. PICCOLINO ², and J. NEYTON ¹

¹ Laboratoire de Neurobiologie, Ecole Normale Supérieure, 46, rue d'Ulm, 75230 Paris Cedex 05, France
² Istituto di Neurofisiologia del C.N.R., Via San Zeno 51, 56100 Pisa, Italy

Light stimulation of the periphery of the receptive field of turtle cones can evoke both transient and sustained increases of the cone Ca²⁺ conductance, which may become regenerative. Such increase in the cone Ca²⁺ conductance evoked by peripheral illumination results from the activation of a poly-synaptic pathway involving a feed-back connexion from the L-horizontal cells (L-HC) to the cones. Thus the hyperpolarization of a L-HC by inward current injection can evoke a Ca²⁺ conductance increase in neigh-bouring cones. The cone Ca²⁺ channels thus activated are likely located at its synaptic endings and probably intervene in the cone transmitter release. Therefore the feed-back connexion between L-HC and cones by modifying the Ca²⁺ conductance of cones could actually modulate the transmitter release from cone synapses. Such feed-back modulation of cone synapses plays a role in the organization of the colour-coded responses of the chromaticity type-horizontal cells and probably of other second order neurones, post-synaptic to the cones. The mechanisms operating the feed-back connexion from L-HC to cones are discussed.

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