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Journal of Experimental Biology 86,39-47 (1980)
Published by Company of Biologists 1980

Neuromuscular Facilitation in Crayfish: Dependence on Potassium and Strophanthidin

C. LEO ORTIZ 1 and R. K. ORKAND 2

1 Biology Board of Studies, University of California Santa Cruz, California 95064
2 Department of Physiology and Pharmacology, School of Dental Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104

1. Long-term facilitation (LTF) and short-term facilitation (STF) at excitatory neuromuscular junctions were studied under conditions of varying [K+]0 and with the addition of strophanthidin.

2. The magnitude of LTF varied inversely with [K+]0, while STF was unaffected.

3. Strophanthidin concentrations greater than 10-5 M greatly increased LTF, but not STF.

4. Both LTF and STF were unaffected by large decreases in excitatory junctional potential amplitude produced by the addition of GABA or Mn+2.

5. The results support the hypothesis that LTF is a consequence of Na+ accumulation in presynaptic terminals and behaves independently of STF.

Submitted on September 20, 1979






© The Company of Biologists Ltd 1980