QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Berridge, M. J. Articles by Rapp, P. E. Search for Related Content PubMed PubMed Citation Articles by Berridge, M. J. Articles by Rapp, P. E.

Journal of Experimental Biology, Vol 81, Issue 1 217-279, Copyright © 1979 by Company of Biologists

JOURNAL ARTICLES

A comparative survey of the function, mechanism and control of cellular oscillators

MJ Berridge and PE Rapp

This review attempts to survey in a uniform manner the available evidence concerning the generation and behaviour of several well-investigated cellular oscillators. Members of two broad classifications are contrasted: (i) cytoplasmic oscillations, where the periodic phenomena is generated by an instability pathway and (ii) membrane oscillators in which a membrane potential rhythm is generated at the membrane. Interactions between the cytoplasmic and membrane compartments are considered and the effects of these interactions on oscillatory behaviour is discussed. Because of their biological importance and the greater body of experimental results, particular attention is directed to a study of membrane potential oscillations. These systems can be approximately classified in two groups: (i) systems in which a periodic potential results from oscillatory changes in permeability and (ii) systems in which potential oscillations result from the periodic activity of an electrogenic pump. The examples considered include the glycolytic oscillator, oscillations in vein contraction in the slime mould Physarum polycephalum, rhythmic aggregation in Dictyostelium discoideum, neural oscillators, the periodic potential in Purkinje fibres and the sino-atrial node and rhythmic behaviour in smooth muscle. Questions considered include the generation of periodic activity, the modulation of the oscillation by drugs and other metabolic and membrane effectors and the question of the functional role of these oscillations.

This article has been cited by other articles:

				S. Shabala, L. Shabala, D. Gradmann, Z. Chen, I. Newman, and S. Mancuso Oscillations in plant membrane transport: model predictions, experimental validation, and physiological implications J. Exp. Bot., January 1, 2006; 57(1): 171 - 184. [Abstract] [Full Text] [PDF]

				T. Mair, C. Warnke, K. Tsuji, and S. C. Muller Control of Glycolytic Oscillations by Temperature Biophys. J., January 1, 2005; 88(1): 639 - 646. [Abstract] [Full Text] [PDF]

				Z. Qiu, B. T. Hyman, and G. W. Rebeck Apolipoprotein E Receptors Mediate Neurite Outgrowth through Activation of p44/42 Mitogen-activated Protein Kinase in Primary Neurons J. Biol. Chem., August 13, 2004; 279(33): 34948 - 34956. [Abstract] [Full Text] [PDF]

				N. J. Lautermilch and N. C. Spitzer Regulation of Calcineurin by Growth Cone Calcium Waves Controls Neurite Extension J. Neurosci., January 1, 2000; 20(1): 315 - 325. [Abstract] [Full Text] [PDF]

				R. TONINI, F. GROHOVAZ, C. A. M. LAPORTA, and M. MAZZANTI Gating mechanism of the nuclear pore complex channel in isolated neonatal and adult mouse liver nuclei FASEB J, August 1, 1999; 13(11): 1395 - 1403. [Abstract] [Full Text]

				D. N. Romashko, E. Marban, and B. O'Rourke Subcellular metabolic transients and mitochondrial redox waves in heart cells PNAS, February 17, 1998; 95(4): 1618 - 1623. [Abstract] [Full Text] [PDF]