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Journal of Experimental Biology, Vol 64, Issue 1 13-23, Copyright © 1976 by Company of Biologists

JOURNAL ARTICLES

The pharmacology of an insect ganglion: actions of carbamylcholine and acetylcholine

DB Sattelle, AS McClay, RJ Dowson and JJ Callec

1. Methods for presenting dose-response data for the ganglionic actions of cholinergic agonists (e.g. carbamylcholine) are compared, using the mannitol-gap technique for electrophysiological recording of synaptic events at the cercal nerve, giant fibre synapse of the sixth abdominal ganglion of the cockroach Periplaneta americana. 2. At concentrations around 10(-5)M, carbamylcholine has no effect on ganglionic polarization but potentiates the monosynaptic EPSP. At 10(-4)M and higher concentrations, ganglionic depolarization is accompanied by a reduction of EPSP. 3. Pretreatment with eserine (10(-6) M) considerably shifts the dose-response curve for acetylcholine so that synaptic transmission is consistently sensitive to 10(-6) M acetylcholine.
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© The Company of Biologists Ltd 1976