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Journal of Experimental Biology 61,443-454 (1974)
Published by Company of Biologists 1974

The Possible Involvement of Brain Microtubules in Memory Fixation

JOHN CRONLY-DILLON ¹, DAVID CARDEN ¹, and CAROLE BIRKS ¹

¹ Visual Sciences Laboratories, Department of Ophthalmic Optics, University of Manchester Institute of Science and Technology, Manchester, England

Goldfish were trained to discriminate between two coloured lights. When colchicine was administered intracranially immediately after training it produced complete retrograde amnesia 2 days later, but the fish displayed considerable retention if instead the injection was given 1.25 h after training. If colchicine was administered 1.25 h before training the fish were able to learn as readily as control fish but then showed retrograde amnesia when tested 2 days later. It is suggested that colchicine may affect memory fixation by interfering with the fast transport of material needed to bring about a structural modification at certain synapses.