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Journal of Experimental Biology 56,493-499 (1972)
Published by Company of Biologists 1972

Accessibility of the Central Nervous Connectives of Anodonta Cygnea to a Compound of Large Molecular Weight

N. J. LANE ¹ and J. E. TREHERNE ¹

¹ A.R.C. Unit of Invertebrate Chemistry and Physiology, Department of Zoology, University of Cambridge

1. Ultrastructural observations on the uptake of an exogenous tracer substance, horseradish peroxidase (M.W. 40,000), have shown that this large molecule can penetrate the neural lamella in intact cerebro-visceral connectives of the lamellibranch, Anodonta cygnea.

2. Peroxidase molecules were also observed to penetrate between the intercellular clefts formed by adjacent membranes of the underlying peripheral glial cell layer and to move extensively into the underlying extracellular spaces.

3. These observations confirm the results of previous electrophysiological, radioisotopic and ultrastructural investigations indicating that a relatively rapid exchange of water-soluble ions and molecules occurs between the blood, or bathing medium, and the extracellular fluid bathing the axon surfaces in intact connectives.