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Journal of Experimental Biology 34,518-528 (1957)
Published by Company of Biologists 1957

Transplantation of Melanomas from Platyfish-Swordtail Hybrids into Embryos of Swordtails, Platyfish and their Hybrids

DOUGLAS G. HUMM ¹, ELOISE E. CLARK ¹, and JANE H. HUMM ¹

¹ Department of Zoology, University of North Carolina, Chapel Hill, North Carolina, U.S.A.

Small pieces of melanoma tissue were obtained from swordtail-platyfish hybrids and grafted into the embryos of swordtails, platyfish and hybrid embryos.

Several types of cells appeared in all the grafts: melanophages, two kinds of melanocytes, and macromelanophores were observed and described.

It was found that the environment of the grafted tissue played a predominant role in the survival of the graft. Grafts to swordtail embryos survived only a short time, whereas grafts to platyfish embryos bearing the gene for macromelanophores survived significantly longer. It was found that hybridization, with or without the macromelanophore gene, presented a still more favourable environment for the growth and migration of pigmented cells.

In no case was it possible to establish and maintain a permanent strain of tumour cells by embryonic transplantation.