QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by MANNELL, W. A. Articles by ROSSITER, R. J. Search for Related Content PubMed Articles by MANNELL, W. A. Articles by ROSSITER, R. J.

Journal of Experimental Biology 31,198-207 (1954)
Published by Company of Biologists 1954

Wallerian Degeneration in the Rat : The Effect of Age on the Concentration of Nucleic Acid and Phospholipid in Intact and Sectioned Nerves

W. A. MANNELL ¹ and R. J. ROSSITER ¹

¹ Department of Biochemistry, University of Western Ontario, London, Canada

1. The wet weight of the sciatic nerve of the rat was significantly correlated with the body weight of the animal for both intact nerves and nerves degenerating after section. The wet weight of sectioned nerves was considerably greater than that of intact nerves.

2. The concentration of both nucleic acid and phospholipid was correlated negatively with the weight of the sciatic nerve. Hence the nerves of younger animals contained a higher concentration of each of these two substances.

3. After nerve section there was an increase in the concentration of nucleic acid and a decrease in the concentration of phospholipid. These changes took place more rapidly in smaller nerves from younger animals than in larger nerves from older animals.