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Journal of Experimental Biology 25,388-394 (1948)
Published by Company of Biologists 1948

The Water-Balance Principle of Crustacean Eye-Stalk Extracts

H. HELLER ¹ and B. SMITH ¹

¹ Department of Pharmacology, University of Bristol

1. Eye-stalks of the brackish water-crab, Carcinus moenas, and of the fresh-water crayfish Potamobius fluviatilis, were extracted according to the pharmacopoeial method for the extraction of posterior pituitary glands.

2. Injection of such eye-stalk extracts resulted in a temporary increase in the body water of frogs. The increase produced by the extract of one eye-stalk of Carcinus was approximately equal to that produced by the injection of 20 milliunits pitocin (=oxytocic fraction of mammalian posterior pituitary extract).

3. The crustacean eye-stalk extracts has no significant oxytocic, chloruretic, or antidiuretic effect.