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First published online January 16, 2009
Journal of Experimental Biology 212, 387-400 (2009)
Published by The Company of Biologists 2009
doi: 10.1242/jeb.024513

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Review

Organellar calcium signalling mechanisms in Drosophila epithelial function

Shireen A. Davies and Selim Terhzaz

Integrative and Systems Biology Group, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 6NU, UK

Author for correspondence (e-mail: s.a.davies{at}bio.gla.ac.uk)

Accepted 3 November 2008

Calcium signalling and calcium homeostasis are essential for life. Studies of calcium signalling thus constitute a major proportion of research in the life sciences, although the majority of these studies are based in cell lines or isolated cells. Epithelial cells and tissues are essential in the regulation of critical physiological processes, including fluid transport; and so the modulation of such processes in vivo by cell-specific calcium signalling is thus of interest. In this review, we describe the approaches to measuring intracellular calcium in the genetically tractable fluid-transporting tissue, the Drosophila Malpighian tubule by targeting cell-specific protein-based calcium reporters to defined regions, cells and intracellular compartments of the intact Malpighian tubule. We also discuss recent findings on the roles of plasma membrane and intracellular calcium channels; and on organellar stores – including mitochondria, Golgi and peroxisomes – in Malpighian tubule function.

Key words: Drosophila, calcium, aequorin, Golgi, mitochondria, peroxisomes

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