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First published online April 20, 2007
Journal of Experimental Biology 210, 1607-1612 (2007)
Published by The Company of Biologists 2007
doi: 10.1242/jeb.004887
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Review Article

Common aging pathways in worms, flies, mice and humans

Stuart K. Kim

Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, CA 94305-5329, USA

e-mail: kim{at}cmgm.stanford.edu

Accepted 8 March 2007

Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many tissues in mice and humans. Recent work has begun to analyze the similarities and differences in transcriptional changes in aging among different species. Most age-related expression changes are specific for a given species, but genes in one pathway (the electron transport chain pathway) show common age regulation in species from worms to humans. Evolutionary theories of aging provide a basis to understand how age regulation of a genetic pathway might be preserved between distantly related species.

Key words: age regulation, gene expression profile, electron transport chain, gene set enrichment analysis, aging, evolution, genomics


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