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First published online May 24, 2005
Journal of Experimental Biology 208, 2083-2090 (2005)
Published by The Company of Biologists 2005
doi: 10.1242/jeb.01605

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The role of myostatin and the calcineurin-signalling pathway in regulating muscle mass in response to exercise training in the rainbow trout Oncorhynchus mykiss Walbaum

C. I. Martin and I. A. Johnston^*

Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Scotland, KY16 8LB, UK

^* Author for correspondence (e-mail: iaj{at}st-andrews.ac.uk)

Accepted 15 March 2005

Rainbow trout Oncorhynchus mykiss Walbaum were exercised at 0.8 and 1.6 body lengths s^-1 for 18 h a day over a 30 day period. Exercise resulted in a 24-30% increase in the average cross-sectional area of fast muscle fibres relative to tank-rested controls. The concentrations of growth factors and transcription factors hypothesised to play a role in regulating exercise-induced muscle fibre hypertrophy were measured. Exercise training resulted in a minor increase in calcineurin localisation in the nucleus. However, nuclear factor of T-cells 2 (NFAT2) nuclear localisation did not follow a pattern that was consistent with NFAT2-mediated transcriptional activity and changes in calcineurin signaling. The active peptide of myostatin, a negative regulator of muscle growth in mammals, was downregulated in exercise groups relative to tank-rested controls, but only by 6-7%. It was concluded that myostatin and calcineurin signaling do not play a major role in regulating exercise-induced muscle hypertrophy in trout.

Key words: rainbow trout, Oncorhynchus mykiss, exercise, muscle, hypertrophy, calcineurin, NFAT2, myostatin

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