spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 15, 2004
Journal of Experimental Biology 207, 3765-3774 (2004)
Published by The Company of Biologists 2004
doi: 10.1242/jeb.01205
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JEB
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wildt, M.
Right arrow Articles by Beltz, B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wildt, M.
Right arrow Articles by Beltz, B. S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Regulation of serotonin levels by multiple light-entrainable endogenous rhythms

M. Wildt1,2, E. M. Goergen1, J. L. Benton1, D. C. Sandeman1 and B. S. Beltz1,*

1 Department of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA
2 Universität Ulm, Neurobiologie, D-89097, Ulm, Germany

* Author for correspondence (e-mail: bbeltz{at}wellesley.edu)

Accepted 15 July 2004

This study examined whether serotonin levels in the brain of the American lobster, Homarus americanus, are under circadian control. Using high-performance liquid chromatography and semi-quantitative immunocytochemical methods, we measured serotonin levels in the brains of lobsters at six time points during a 24-h period. Lobsters were maintained for 2 weeks on a 12 h:12 h light:dark cycle followed by 3 days of constant darkness. Under these conditions, brain serotonin levels varied rhythmically, with a peak before subjective dusk and a trough before subjective dawn. This persistent circadian rhythm in constant darkness indicates that serotonin levels are controlled by an endogenous clock. Animals exposed to a shifted light cycle for >10 days, followed by 3 days in constant darkness, demonstrate that this rhythm is light entrainable. Separate analyses of two pairs of large deutocerebral neuropils, the accessory and olfactory lobes, show that serotonin levels in these functionally distinct areas also exhibit circadian rhythms but that these rhythms are out of phase with one another. The olfactory and accessory lobe rhythms are also endogenous and light entrainable, suggesting the presence of multiple clock mechanisms regulating serotonin levels in different brain regions.

Key words: Homarus americanus, Crustacea, neurogenesis, 5-hydroxytryptamine, central nervous system


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?

Related articles in JEB:

SEROTONIN'S CIRCADIAN RHYTHM
Kathryn Phillips
JEB 2004 207: i. [Full Text]  



This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
K. Phillips
SEROTONIN'S CIRCADIAN RHYTHM
J. Exp. Biol., October 1, 2004; 207(21): i - i.
[Full Text] [PDF]


© The Company of Biologists Ltd 2004