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The Journal of Experimental Biology 206, 687-692 (2003)
doi: 10.1242/jeb.00146

Central effects of various ligands on drinking behavior in eels acclimated to seawater

Tomohiro Kozaka, Yasuaki Fujii and Masaaki Ando^*

Laboratory of Integrative Physiology, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan

^* Author for correspondence (e-mail: mando{at}hiroshima-u.ac.jp)

Accepted 18 November 2002

Intracranial injection of eel angiotensin II (eANG II, 5x10^-13-5x10^-8 mol), acetylcholine (ACh, 5x10^-12-5x10^-9 mol), substance P (5x10^-10 mol) and isoproterenol (a ß-adrenoceptor agonist, 5x10^-11-5x10^-9 mol) enhanced water intake in the seawater eel. The effects of eANG II, ACh and isoproterenol were dose-dependent. By contrast, water intake was inhibited by intracranial injection of eel atrial natriuretic peptide (eANP, 5x10^-13-5x10^-10 mol), serotonin (5-HT, 5x10^-12-5x10^-8 mol), ghrelin (5x10^-12-5x10^-10 mol), -amino butyric acid (GABA, 5x10^-11-5x10^-8 mol), prolactin (PRL, 5x10^-10-5x10^-9 mol), arginine vasotocin (AVT, 5x10^-12 mol), vasoactive intestinal peptide (VIP, 5x10^-11 mol), noradrenaline (5x10^-9 mol l^-1) and phenylephrine (-adrenoceptor agonist, 5x10^-11-5x10^-9 mol). The inhibitory effects of eANP, 5-HT, ghrelin, GABA, PRL and phenylephrine were dose-dependent. The intracranial stimulatory effect of eANG II was relatively long-lasting compared with the intravenous effect. The stimulatory effect of intravenous eANG II disappeared immediately, and was followed by an inhibition, which could be well explained by an increase in eANP secretion from the atrium.

Key words: seawater eel, Anguilla japonica, drinking behavior, intracranial administration, intravenous administration, angiotensin II, atrial natriuretic peptide, circumventricular organ

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