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The Journal of Experimental Biology 206, 431-443 (2003)
doi: 10.1242/jeb.00077

Neurohormonal and glutamatergic neuronal control of the cardioarterial valves in the isopod crustacean Bathynomus doederleini

Yoko F.-Tsukamoto and Kiyoaki Kuwasawa^*

Department of Biological Sciences, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji 192-0397, Japan

^* Author for correspondence (e-mail: kuwasawa-kiyoaki{at}c.metro-u.ac.jp)

Accepted 14 October 2002

The heart of Bathynomus doederleini gives rise to an anterior median artery (AMA), one pair of anterior lateral arteries (ALAs) and five pairs of lateral arteries (LAs). Cardioarterial valves are located at the junctions between the heart and arteries, each composed of a pair of muscular flaps. All valves of the AMA and the ALAs receive valve excitatory (constrictor) nerves (VEs). The valves of the ALAs receive dual innervation from both constrictor and inhibitor (dilator) nerves, while the valves of the AMA receive innervation from a constrictor nerve alone. The effects of candidate neurohormones on cardioarterial valves were examined by measuring the pressure in each artery at which haemolymph flows out of the heart through the valve. Serotonin, octopamine, norepinephrine, glutamate (Glu) and proctolin constricted the cardioarterial valves and thus decreased the arterial pressure in all the arteries. Dopamine also decreased the arterial pressure of arteries except for the ALAs, in which pressure was increased. Among the neurohormones exerting excitatory effects on the valves, only Glu depolarized the membrane potential of valve muscle cells. The glutamatergic agonists kainate and quisqualate also depolarized the valve muscle cells of the AMA. Excitatory junctional potentials produced in the valves of the AMA in response to the stimulation of a VE were blocked by the glutamatergic antagonists Joro spider toxin and MK-801. Glu is the likeliest candidate for a neurotransmitter for the VEs.

Key words: neuronal control, neurotransmitter, cardioarterial valves, neurohormone, serotonin, dopamine, glutamate, glutamatergic agonist, glutamatergic antagonist, Joro spider toxin, valve excitatory nerve, isopod crustacean, Bathynomus doederleini

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