spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 23, 2003
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JEB
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dunachie, S. J.
Right arrow Articles by Hill, A. V. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dunachie, S. J.
Right arrow Articles by Hill, A. V. S.
The Journal of Experimental Biology 206, 3771-3779 (2003)
doi: 10.1242/jeb.00642


Review Article

Prime-boost strategies for malaria vaccine development

Susanna J. Dunachie* and Adrian V. S. Hill

Centre for Clinical Vaccinology and Tropical Medicine,, University of Oxford, Churchill Hospital, Old Road, Oxford OX3 7LJ, UK

* Author for correspondence (e-mail: susie.dunachie{at}ndm.ox.ac.uk)

Accepted 1 July 2003

Malaria is an intracellular pathogen, for which an effective vaccine is likely to require induction of cell-mediated immunity. Immunisation approaches that stimulate strong and persistent levels of effector T-cells are being sought by many researchers. DNA vaccines, recombinant protein and viral vectors were amongst the vaccine delivery systems that appeared promising for the generation of cellular immunity, and in some initial studies in small animals this goal was achieved. However, clinical trials of these candidate vaccines when used alone or in repeated homologous boosting regimes have been disappointing, with short-lived low levels of induced specific T-cell responses. Recent years have seen the development of immunisation strategies using a combination of different antigen delivery systems encoding the same epitopes or antigen, delivered at an interval of a few weeks apart. This sequential immunisation approach with different vectors is known as heterologous prime-boosting and is capable of inducing greatly enhanced and persistent levels of CD8+ T-cells and Th1-type CD4+ T-cells compared to homologous boosting. This review will summarise the key pre-clinical studies of prime-boost strategy and outline recent progress in clinical trials of this approach. Possible mechanisms of action and potential improvements to existing delivery systems will be discussed. The prime-boost approach represents an encouraging step towards establishing an effective preventative vaccine to one of the world's greatest killers.

Key words: vaccine, malaria, prime-boost strategy, T-cell


Related articles in JEB:

MALARIA IN EXPERIMENTAL BIOLOGY
Kathryn Phillips
JEB 2003 206: 3723-3726. [Full Text]  



This article has been cited by other articles:


Home page
Infect. Immun.Home page
A. Rodriguez, J. Goudsmit, A. Companjen, R. Mintardjo, G. Gillissen, D. Tax, J. Sijtsma, G. J. Weverling, L. Holterman, D. E. Lanar, et al.
Impact of Recombinant Adenovirus Serotype 35 Priming versus Boosting of a Plasmodium falciparum Protein: Characterization of T- and B-Cell Responses to Liver-Stage Antigen 1
Infect. Immun., April 1, 2008; 76(4): 1709 - 1718.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
M. Chinchilla, M. F. Pasetti, S. Medina-Moreno, J. Y. Wang, O. G. Gomez-Duarte, R. Stout, M. M. Levine, and J. E. Galen
Enhanced Immunity to Plasmodium falciparum Circumsporozoite Protein (PfCSP) by Using Salmonella enterica Serovar Typhi Expressing PfCSP and a PfCSP-Encoding DNA Vaccine in a Heterologous Prime-Boost Strategy
Infect. Immun., August 1, 2007; 75(8): 3769 - 3779.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. I. Naslund, C. Uyttenhove, E. K. L. Nordstrom, D. Colau, G. Warnier, M. Jondal, B. J. Van den Eynde, and P. Liljestrom
Comparative Prime-Boost Vaccinations Using Semliki Forest Virus, Adenovirus, and ALVAC Vectors Demonstrate Differences in the Generation of a Protective Central Memory CTL Response against the P815 Tumor
J. Immunol., June 1, 2007; 178(11): 6761 - 6769.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
F. Castellino and R. N. Germain
Chemokine-Guided CD4+ T Cell Help Enhances Generation of IL-6R{alpha}highIL-7R{alpha}high Prememory CD8+ T Cells
J. Immunol., January 15, 2007; 178(2): 778 - 787.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
R. Liang, J. V. van den Hurk, L. A. Babiuk, and S. van Drunen Littel-van den Hurk
Priming with DNA encoding E2 and boosting with E2 protein formulated with CpG oligodeoxynucleotides induces strong immune responses and protection from Bovine viral diarrhea virus in cattle.
J. Gen. Virol., October 1, 2006; 87(Pt 10): 2971 - 2982.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Med.Home page
D. M. Jelley-Gibbs, J. P. Dibble, S. Filipson, L. Haynes, R. A. Kemp, and S. L. Swain
Repeated stimulation of CD4 effector T cells can limit their protective function
J. Exp. Med., April 4, 2005; 201(7): 1101 - 1112.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
S. Korten, R. J. Anderson, C. M. Hannan, E. G. Sheu, R. Sinden, S. Gadola, M. Taniguchi, and A. V. S. Hill
Invariant V{alpha}14 Chain NKT Cells Promote Plasmodium berghei Circumsporozoite Protein-Specific Gamma Interferon- and Tumor Necrosis Factor Alpha-Producing CD8+ T Cells in the Liver after Poxvirus Vaccination of Mice
Infect. Immun., February 1, 2005; 73(2): 849 - 858.
[Abstract] [Full Text] [PDF]


Home page
J. Exp. Biol.Home page
D. L. Doolan, J. C. Aguiar, W. R. Weiss, A. Sette, P. L. Felgner, D. P. Regis, P. Quinones-Casas, J. R. Yates III, P. L. Blair, T. L. Richie, et al.
Utilization of genomic sequence information to develop malaria vaccines
J. Exp. Biol., November 1, 2003; 206(21): 3789 - 3802.
[Abstract] [Full Text] [PDF]




© The Company of Biologists Ltd 2003