|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Review Article |
Myoglobin function reassessed
Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
* Author for correspondence (e-mail: bwitten{at}aecom.yu.edu)
Accepted 13 January 2003
The heart and those striated muscles that contract for long periods, having available almost limitless oxygen, operate in sustained steady states of low sarcoplasmic oxygen pressure that resist change in response to changing muscle work or oxygen supply. Most of the oxygen pressure drop from the erythrocyte to the mitochondrion occurs across the capillary wall. Within the sarcoplasm, myoglobin, a mobile carrier of oxygen, is developed in response to mitochondrial demand and augments the flow of oxygen to the mitochondria. Myoglobin-facilitated oxygen diffusion, perhaps by virtue of reduction of dimensionality of diffusion from three dimensions towards two dimensions in the narrow spaces available between mitochondria, is rapid relative to other parameters of cell respiration. Consequently, intracellular gradients of oxygen pressure are shallow, and sarcoplasmic oxygen pressure is nearly the same everywhere. Sarcoplasmic oxygen pressure, buffered near 0.33 kPa (2.5 torr; equivalent to approximately 4 µmol l-1 oxygen) by equilibrium with myoglobin, falls close to the operational Km of cytochrome oxidase for oxygen, and any small increment in sarcoplasmic oxygen pressure will be countered by increased oxygen utilization. The concentration of nitric oxide within the myocyte results from a balance of endogenous synthesis and removal by oxymyoglobin-catalyzed dioxygenation to the innocuous nitrate. Oxymyoglobin, by controlling sarcoplasmic nitric oxide concentration, helps assure the steady state in which inflow of oxygen into the myocyte equals the rate of oxygen consumption.
Key words: myoglobin, oxygen, facilitated diffusion, dimensionality in diffusion, heart, red skeletal muscle, nitric oxide, mitochondria, cytochrome oxidase, Krogh cylinder
This article has been cited by other articles:
|
|
 |
|
  W. F. Alzawahra, M. A. H. Talukder, X. Liu, A. Samouilov, and J. L. Zweier Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H499 - H508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Silvestri, A. Pagani, and C. Camaschella Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis Blood, January 15, 2008; 111(2): 924 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cohen and K. Schulten O2 Migration Pathways Are Not Conserved across Proteins of a Similar Fold Biophys. J., November 15, 2007; 93(10): 3591 - 3600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Mocny, J. S. Olson, and T. D. Connell Passively Released Heme from Hemoglobin and Myoglobin Is a Potential Source of Nutrient Iron for Bordetella bronchiseptica Infect. Immun., October 1, 2007; 75(10): 4857 - 4866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Brown and V. Borutaite Nitric oxide and mitochondrial respiration in the heart Cardiovasc Res, July 15, 2007; 75(2): 283 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Wittenberg and B. A. Wittenberg Myoglobin-enhanced oxygen delivery to isolated cardiac mitochondria J. Exp. Biol., June 15, 2007; 210(12): 2082 - 2090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Robach, G. Cairo, C. Gelfi, F. Bernuzzi, H. Pilegaard, A. Vigano, P. Santambrogio, P. Cerretelli, J. A. L. Calbet, S. Moutereau, et al. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle Blood, June 1, 2007; 109(11): 4724 - 4731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-C. Lin, U. Kreutzer, and T. Jue Anisotropy and Temperature Dependence of Myoglobin Translational Diffusion in Myocardium: Implication for Oxygen Transport and Cellular Architecture Biophys. J., April 1, 2007; 92(7): 2608 - 2620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shiva, Z. Huang, R. Grubina, J. Sun, L. A. Ringwood, P. H. MacArthur, X. Xu, E. Murphy, V. M. Darley-Usmar, and M. T. Gladwin Deoxymyoglobin Is a Nitrite Reductase That Generates Nitric Oxide and Regulates Mitochondrial Respiration Circ. Res., March 16, 2007; 100(5): 654 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Vernier, A. Chenal, H. Vitrac, R. Barumandzadhe, C. Montagner, and V. Forge Interactions of apomyoglobin with membranes: Mechanisms and effects on heme uptake Protein Sci., March 1, 2007; 16(3): 391 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-C. Lin, U. Kreutzer, and T. Jue Myoglobin translational diffusion in rat myocardium and its implication on intracellular oxygen transport J. Physiol., January 15, 2007; 578(2): 595 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. P.A. Mammen, J. M. Shelton, Q. Ye, S. B. Kanatous, A. J. McGrath, J. A. Richardson, and D. J. Garry Cytoglobin Is a Stress-responsive Hemoprotein Expressed in the Developing and Adult Brain J. Histochem. Cytochem., December 1, 2006; 54(12): 1349 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cohen, A. Arkhipov, R. Braun, and K. Schulten Imaging the Migration Pathways for O2, CO, NO, and Xe Inside Myoglobin Biophys. J., September 1, 2006; 91(5): 1844 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Rezende, F. R. Gomes, J. L. Malisch, M. A. Chappell, and T. Garland Jr. Maximal oxygen consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary wheel running J Appl Physiol, August 1, 2006; 101(2): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ganitkevich, S. Reil, B. Schwethelm, T. Schroeter, and K. Benndorf Dynamic Responses of Single Cardiomyocytes to Graded Ischemia Studied by Oxygen Clamp in On-Chip Picochambers Circ. Res., July 21, 2006; 99(2): 165 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Roesner, T. Hankeln, and T. Burmester Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio) J. Exp. Biol., June 1, 2006; 209(11): 2129 - 2137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chung, S.-J. Huang, A. Glabe, and T. Jue Implication of CO inactivation on myoglobin function Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1616 - C1624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Sidell and K. M. O'Brien When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes J. Exp. Biol., May 15, 2006; 209(10): 1791 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ostojic, D. S. Sakaguchi, Y. de Lathouder, M. S. Hargrove, J. T. Trent III, Y. H. Kwon, R. H. Kardon, M. H. Kuehn, D. M. Betts, and S. Grozdanic Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons. Invest. Ophthalmol. Vis. Sci., March 1, 2006; 47(3): 1016 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Riggs and T. A. Gorr A globin in every cell? PNAS, February 21, 2006; 103(8): 2469 - 2470. [Full Text] [PDF]
|
|
|
|
|
|
G. Kemp, L. F. Ferreira, and T. J. Barstow Kinetics of muscle oxygen use, oxygen content, and blood flow during exercise J Appl Physiol, December 1, 2005; 99(6): 2463 - 2469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. van der Laarse, A. L. des Tombe, B. J. van Beek-Harmsen, M. B. E. Lee-de Groot, and R. T. Jaspers Krogh's diffusion coefficient for oxygen in isolated Xenopus skeletal muscle fibers and rat myocardial trabeculae at maximum rates of oxygen consumption J Appl Physiol, December 1, 2005; 99(6): 2173 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kitagawa, T. Yamazaki, T. Akiyama, M. Sugimachi, K. Sunagawa, and H. Mori Microdialysis separately monitors myocardial interstitial myoglobin during ischemia and reperfusion Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H924 - H930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. de Sanctis, S. Dewilde, C. Vonrhein, A. Pesce, L. Moens, P. Ascenzi, T. Hankeln, T. Burmester, M. Ponassi, M. Nardini, et al. Bishistidyl Heme Hexacoordination, a Key Structural Property in Drosophila melanogaster Hemoglobin J. Biol. Chem., July 22, 2005; 280(29): 27222 - 27229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bentmann, M. Schmidt, S. Reuss, U. Wolfrum, T. Hankeln, and T. Burmester Divergent Distribution in Vascular and Avascular Mammalian Retinae Links Neuroglobin to Cellular Respiration J. Biol. Chem., May 27, 2005; 280(21): 20660 - 20665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Flogel, T. Laussmann, A. Godecke, N. Abanador, M. Schafers, C. D. Fingas, S. Metzger, B. Levkau, C. Jacoby, and J. Schrader Lack of Myoglobin Causes a Switch in Cardiac Substrate Selection Circ. Res., April 29, 2005; 96(8): e68 - e75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Arcovito, D. C. Lamb, G. U. Nienhaus, J. L. Hazemann, M. Benfatto, and S. D. Longa Light-Induced Relaxation of Photolyzed Carbonmonoxy Myoglobin: A Temperature-Dependent X-Ray Absorption Near-Edge Structure (XANES) Study Biophys. J., April 1, 2005; 88(4): 2954 - 2964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. S. Rayner, B.-J. Wu, M. Raftery, R. Stocker, and P. K. Witting Human S-Nitroso Oxymyoglobin Is a Store of Vasoactive Nitric Oxide J. Biol. Chem., March 18, 2005; 280(11): 9985 - 9993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roesner, C. Fuchs, T. Hankeln, and T. Burmester A Globin Gene of Ancient Evolutionary Origin in Lower Vertebrates: Evidence for Two Distinct Globin Families in Animals Mol. Biol. Evol., January 1, 2005; 22(1): 12 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Fago, C. Hundahl, S. Dewilde, K. Gilany, L. Moens, and R. E. Weber Allosteric Regulation and Temperature Dependence of Oxygen Binding in Human Neuroglobin and Cytoglobin: MOLECULAR MECHANISMS AND PHYSIOLOGICAL SIGNIFICANCE J. Biol. Chem., October 22, 2004; 279(43): 44417 - 44426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Ordway and D. J. Garry Myoglobin: an essential hemoprotein in striated muscle J. Exp. Biol., September 15, 2004; 207(20): 3441 - 3446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fuchs, V. Heib, L. Kiger, M. Haberkamp, A. Roesner, M. Schmidt, D. Hamdane, M. C. Marden, T. Hankeln, and T. Burmester Zebrafish Reveals Different and Conserved Features of Vertebrate Neuroglobin Gene Structure, Expression Pattern, and Ligand Binding J. Biol. Chem., June 4, 2004; 279(23): 24116 - 24122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Burmester and T. Hankeln Neuroglobin: A Respiratory Protein of the Nervous System Physiology, June 1, 2004; 19(3): 110 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tiravanti, A. Samouilov, and J. L. Zweier Nitrosyl-Heme Complexes Are Formed in the Ischemic Heart: EVIDENCE OF NITRITE-DERIVED NITRIC OXIDE FORMATION, STORAGE, AND SIGNALING IN POST-ISCHEMIC TISSUES J. Biol. Chem., March 19, 2004; 279(12): 11065 - 11073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kanai and J. Peterson Function and regulation of mitochondrially produced nitric oxide in cardiomyocytes Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H11 - H12. [Full Text] [PDF]
|
|
|
|
|
|
J. Peterson, A. J. Kanai, and L. L. Pearce A mitochondrial role for catabolism of nitric oxide in cardiomyocytes not involving oxymyoglobin Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H55 - H58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Pearce, E. L. Bominaar, B. C. Hill, and J. Peterson Reversal of Cyanide Inhibition of Cytochrome c Oxidase by the Auxiliary Substrate Nitric Oxide: AN ENDOGENOUS ANTIDOTE TO CYANIDE POISONING? J. Biol. Chem., December 26, 2003; 278(52): 52139 - 52145. [Abstract] [Full Text] [PDF]
|
|
