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The Journal of Experimental Biology 206, 1977-1984 (2003)
doi: 10.1242/jeb.00240

Review Article

Actin comet tails, endosomes and endosymbionts

Kammy Fehrenbacher^*, Thomas Huckaba^*, Hyeong-Cheol Yang, Istvan Boldogh and Liza Pon

Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA
^* These individuals contributed equally to this manuscript

Author for correspondence (e-mail: lap5{at}columbia.edu)

Accepted 15 January 2003

The Arp2/3 complex consists of seven highly conserved and tightly associated subunits, two of which are the actin-related proteins Arp2 and Arp3. One of the best-studied functions of the Arp2/3 complex is to stimulate actin nucleation and force production at the leading edge of motile cells. What is now clear is that Arp2/3-complex-mediated force production drives many intracellular movements, including movement of bacterial pathogens in infected host cells, internalization of extracellular materials via phagocytosis and endocytosis, and movement of mitochondria during cell division in budding yeast. Here, we describe recent advances in the mechanisms underlying Arp2/3 complex-driven intracellular movement.

Key words: actin, cytoskeleton, endocytosis, mitochondria, organelle movement, pathogen

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