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The Journal of Experimental Biology 205, 1233-1240 (2002)
© 2002 The Company of Biologists Limited

Drosophila as a new model organism for the neurobiology of aggression?

Andrea Baier*, Britta Wittek* and Björn Brembs{dagger}

Lehrstuhl für Genetik und Neurobiologie, Biozentrum, Am Hubland, D-97074 Würzburg, Germany
* These authors contributed equally to this work

{dagger} Author for correspondence at present address: Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, University of Texas-Houston Medical School, Houston, Texas 77030, USA (e-mail: bjoern{at}brembs.net )

Accepted 22 February 2002

We report here the effects of several neurobiological determinants on aggressive behaviour in the fruitfly Drosophila melanogaster. This study combines behavioural, transgenic, genetic and pharmacological techniques that are well established in the fruitfly, in the novel context of the neurobiology of aggression. We find that octopamine, dopamine and a region in the Drosophila brain called the mushroom bodies, all profoundly influence the expression of aggressive behaviour. Serotonin had no effect. We conclude that Drosophila, with its advanced set of molecular tools and its behavioural richness, has the potential to develop into a new model organism for the study of the neurobiology of aggression.

Key words: Drosophila melanogaster, aggression, fighting behaviour, amine, mushroom body


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