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Post-prandial blood flow to the gastrointestinal tract is not compromised during hypoxia in the sea bass Dicentrarchus labrax
1 Department of Zoology, University of Göteborg, Box 463, S-405 30
Göteborg, Sweden
2 CREMA-L'Houmeau, (CNRS-IFREMER), France
* Author for correspondence (e-mail: M.Axelsson{at}zool.gu.se)
Accepted 6 June 2002
The hypothesis that the increase in post-prandial splanchnic blood flow will be reduced during hypoxia to prioritise blood flow to other organs was tested by measuring cardiac output and gut blood flow during a stepwise hypoxic challenge (five steps, from 20.6 to 3.9 kPa, 5 min of exposure to each level) before and after feeding (equivalent to 2.9% of body mass). Splanchnic blood flow, both absolute and relative to cardiac output, increased after feeding. Mean post-prandial gut blood flow increased by 71% (from 9.6±1.6 to 14.9±1.6 ml min-1 kg-1, means ± S.E.M.). Before feeding, gut blood flow was 24.0% of cardiac output, and this increased significantly 24 h after feeding to 34.0%. The absolute post-prandial increase in gut blood flow (5.3±0.9 ml min-1 kg-1) was paralleled by an increase in cardiac output (5.4±2.1 ml min-1 kg-1). Hypoxia decreased gut blood flow significantly from 9.6±1.6 to 3.7±1.1 ml min-1 kg-1, corresponding to a decrease in relative gut blood flow from 24 % to 13%. Contrary to our initial hypothesis, and although post-prandial absolute blood flow decreases during hypoxia, the relative proportion of cardiac output reaching the gut did not decrease (34.6% pre-hypoxia versus 26.7% during hypoxia), unlike the situation in non-feeding fish. We propose that, following feeding, relative gut blood flow is maintained because splanchnic hyperaemia occurs as a result of the release of local factors; consequently the reflex vasoconstriction of the gastrointestinal vasculature during hypoxia is not as effective in decreasing gut blood flow as it was before feeding because local hyperaemia out-competes the reflex regulation.
Key words: gastrointestinal blood flow, cardiac output, hypoxia, post-prandial, sea bass, Dicentrarchus labrax
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