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The Journal of Experimental Biology 205, 13-24 (2002)
© 2002 The Company of Biologists Limited

Three-dimensional morphometry of spinal cord injury following polyethylene glycol treatment

Bradley S. Duerstock and Richard B. Borgens*

Center for Paralysis Research, Institute for Applied Neurology, Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-1244, USA

*e-mail: cpr{at}vet.purdue.edu

Accepted 16 October 2001

We are developing a novel means of restoring function after severe acute spinal cord injury. This involves a brief application of polyethylene glycol (PEG) to the site of injury. In the companion paper, we have shown that a delayed application of PEG can produce strikingly significant physiological and behavioral recovery in 90–100 % of spinal-cord-injured guinea pigs. In the present paper, we used three-dimensional computer reconstructions of PEG-treated and sham-treated spinal cords to determine whether the pathological character of a 1-month-old injury is ameliorated by application of PEG. Using a novel isocontouring algorithm, we show that immediate PEG treatment and treatment delayed by up to 7 h post-injury statistically increased the volume of intact spinal parenchyma and reduced the amount of cystic cavitation. Furthermore, in PEG-treated animals, the lesion was more focal and less diffuse throughout the damaged segment of the spinal cord, so that control cords showed a significantly extended lesion surface area. This three-dimensional computer evaluation showed that the functional recovery produced by topical application of a hydrophilic polymer is accompanied by a reduction in spinal cord damage.

Key words: three-dimensional reconstruction, computer visualization, morphometry, spinal cord injury, neurotrauma, cavitation.


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R. B. Borgens, R. Shi, and D. Bohnert
Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol
J. Exp. Biol., January 1, 2002; 205(1): 1 - 12.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2002