|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Selection for high voluntary wheel-running increases speed and intermittency in house mice (Mus domesticus)
Department of Zoology, 430 Lincoln Drive, University of Wisconsin-Madison, Madison, WI 53706, USA
Present address: Department of Biology, University of California Riverside, Riverside, CA 92521-0427, USA
*e-mail: igirard{at}ucstaff.wisc.edu
Accepted 2 October 2001
In nature, many animals use intermittent rather than continuous locomotion. In laboratory studies, intermittent exercise regimens have been shown to increase endurance compared with continuous exercise. We hypothesized that increased intermittency has evolved in lines of house mice (Mus domesticus) that have been selectively bred for high voluntary wheel-running (wheel diameter 1.12 m) activity. After 23 generations, female mice from four replicate selection lines ran 2.7 times more revolutions per day than individuals from four random-bred control lines. To measure instantaneous running speeds and to quantify intermittency, we videotaped mice (N=41) during a 5-min period of peak activity on night 6 of a 6-day exposure to wheels. Compared with controls (20 revs min–1 while actually running), selection-line females (41 revs min–1) ran significantly faster. These instantaneous speeds closely matched the computer-recorded speeds over the same 5-min period. Selection-line females also ran more intermittently, with shorter (10.0 s bout–1) and more frequent (7.8 bouts min–1) bouts than controls (16.8 s bout–1, 3.4 bouts min–1). Inter-bout pauses were also significantly shorter in selection-line (2.7 s) than in control-line (7.4 s) females. We hypothesize that intermittency of locomotion is a key feature allowing the increased wheel-running performance at high running speeds in selection-line mice.
Key words: activity, evolution, exercise, intermittent locomotion, selection, wheel-running, house mouse, Mus domesticus.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  A. J. Nelson, J. M. Juraska, T. I. Musch, and G. A. Iwamoto Neuroplastic adaptations to exercise: neuronal remodeling in cardiorespiratory and locomotor areas J Appl Physiol, December 1, 2005; 99(6): 2312 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Syme, K. Evashuk, B. Grintuch, E. L. Rezende, and T. Garland Jr. Contractile abilities of normal and "mini" triceps surae muscles from mice (Mus domesticus) selectively bred for high voluntary wheel running J Appl Physiol, October 1, 2005; 99(4): 1308 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Billat, E. Mouisel, N. Roblot, and J. Melki Inter- and intrastrain variation in mouse critical running speed J Appl Physiol, April 1, 2005; 98(4): 1258 - 1263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Belter, H. V. Carey, and T. Garland Jr. Effects of voluntary exercise and genetic selection for high activity levels on HSP72 expression in house mice J Appl Physiol, April 1, 2004; 96(4): 1270 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Houle-Leroy, H. Guderley, J. G. Swallow, and T. Garland Jr. Artificial selection for high activity favors mighty mini-muscles in house mice Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R433 - R443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. J. Kemi, J. P. Loennechen, U. Wisloff, and O. Ellingsen Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy J Appl Physiol, October 1, 2002; 93(4): 1301 - 1309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Girard and T. Garland Jr. Plasma corticosterone response to acute and chronic voluntary exercise in female house mice J Appl Physiol, April 1, 2002; 92(4): 1553 - 1561. [Abstract] [Full Text] [PDF]
|
|
