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Nitric oxide induces centrally generated motor patterns in the locust suboesophageal ganglion
Institut für Biologie II, Rheinisch-Westfälische Technische Hochschule Aachen, 52056 Aachen, Germany
*Present address: Wellcome Laboratory for Molecular Pharmacology, University College London, Gower Street, London WC1E 6BT, UK (e-mail: g.rast{at}ucl.ac.uk)
Accepted July 13, 2001
The stimulatory effects of nitric oxide (NO) on central motor pattern generation in isolated locust suboesophageal ganglia (SOGs) were studied using extracellular recordings from motor nerves. Different NO donor molecules and a specific inhibitor of soluble guanylyl cyclases were used to confirm that the observed motor pattern occurred in response to activation of the NO/cyclic GMP signalling pathway. Experiments with muscarinic agonists and antagonists showed that the NO-induced motor pattern is generated independently from the motor pattern induced by muscarinic agonists described previously. Staining for NADPH-diaphorase and an antiserum directed against cyclic GMP were used to identify neurones representing potential sources of NO and their target cells within the SOG. Using intracellular dye injection and backfilling of peripheral nerves in combination with anti-cGMP immunohistochemistry, it was shown that identified efferent neurones involved in the mandibular motor pattern are potential target cells of NO.
Key words: nitric oxide, soluble guanylyl cyclase, pilocarpine, migratory locust, Locusta migratoria.
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