spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adams, C. S.
Right arrow Articles by Blank, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adams, C. S.
Right arrow Articles by Blank, J. L.

Journal of Experimental Biology, Vol 204, Issue 10 1729-1734, Copyright © 2001 by Company of Biologists

JOURNAL ARTICLES

A novel mechanism of body mass regulation

CS Adams, AI Korytko and JL Blank
Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Levy Research Building, Philadelphia, PA 19104-6002, USA, Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA and Department of Biological Sciences, Kent State University, Kent, OH 44242, USA. adamsc@biochem.dental.upenn.edu

While significant attention has been devoted to the identification of hormonal factors that control body mass, little attention has been paid to the role of mechanical loading on animal mass. Here, we provide evidence that intraperitoneal implantation of metabolically inert mass results in a compensatory reduction in tissue mass. Deer mice (Peromyscus maniculatus) were surgically implanted with weights of 1, 2 or 3 g. There was a resulting loss of tissue mass (total body mass minus implant mass) that was proportional to the mass of the implant. This reduction in tissue mass followed a reduction in food intake in animals with 3 g implants. Evaluation of body composition failed to identify any single component that contributed to the loss of tissue mass. Removal of implants led to a transient restoration of body mass to levels similar to the total body mass of those control animals in which the implant had not been removed. However, within 12 days of implant removal, body mass again declined to the level seen before implant removal. These results suggest the existence of a set point that is sensitive to changes in the perception of mass and that is transduced via neural pathways.


This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
R. D. Stevenson and W. A. Woods Jr
Condition indices for conservation: new uses for evolving tools
Integr. Comp. Biol., December 1, 2006; 46(6): 1169 - 1190.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
P. Wiedmer, M. Boschmann, and S. Klaus
Gender dimorphism of body mass perception and regulation in mice
J. Exp. Biol., July 15, 2004; 207(16): 2859 - 2866.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. N. Wade
Regulation of body fat content?
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R14 - R15.
[Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
S. L. Black, C. S. Adams, and J. L. Blank
Does weight gain lead to weight loss?
J. Exp. Biol., August 1, 2003; 206(15): 2535 - 2537.
[Full Text] [PDF]


© The Company of Biologists Ltd 2001