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Journal of Experimental Biology, Vol 203, Issue 8 1253-1263, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
RH Wenger
Institute of Physiology, University of Zurich-Irchel, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. rwenger@physiol.unizh.ch
Oxygen is essential to the life of all aerobic organisms. Virtually every cell type is able to sense a limited oxygen supply (hypoxia) and specifically to induce a set of oxygen-regulated genes. This review summarizes current concepts of mammalian oxygen-sensing and signal-transduction pathways. Since the discovery of the hypoxia-inducible factors (HIFs), a great deal of progress has been made in our comprehension of how hypoxia induces the expression of oxygen-regulated genes. The alpha subunit of the heterodimeric transcription factors HIF-1, 2 and 3 is unstable under normoxia but is rapidly stabilized upon exposure to hypoxic conditions. Following heterodimerization with the constitutively expressed beta subunit, HIFs activate the transcription of an increasing number of genes involved in maintaining oxygen homeostasis at the cellular, local and systemic levels.
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 R. Airley, J. Loncaster, S. Davidson, M. Bromley, S. Roberts, A. Patterson, R. Hunter, I. Stratford, and C. West Glucose Transporter Glut-1 Expression Correlates with Tumor Hypoxia and Predicts Metastasis-free Survival in Advanced Carcinoma of the Cervix Clin. Cancer Res., April 1, 2001; 7(4): 928 - 934. [Abstract] [Full Text]
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G. L. Semenza HIF-1 and human disease: one highly involved factor Genes & Dev., August 15, 2000; 14(16): 1983 - 1991. [Full Text]
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R. M. Wanner, P. Spielmann, D. M. Stroka, G. Camenisch, I. Camenisch, A. Scheid, D. R. Houck, C. Bauer, M. Gassmann, and R. H. Wenger Epolones induce erythropoietin expression via hypoxia-inducible factor-1alpha activation Blood, August 15, 2000; 96(4): 1558 - 1565. [Abstract] [Full Text] [PDF]
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M. Ivan, K. Kondo, H. Yang, W. Kim, J. Valiando, M. Ohh, A. Salic, J. M. Asara, W. S. Lane, and W. G. Kaelin Jr. HIFalpha Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing Science, April 20, 2001; 292(5516): 464 - 468. [Abstract] [Full Text]
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V. Srinivas, I. Leshchinsky, N. Sang, M. P. King, A. Minchenko, and J. Caro Oxygen Sensing and HIF-1 Activation Does Not Require an Active Mitochondrial Respiratory Chain Electron-transfer Pathway J. Biol. Chem., June 15, 2001; 276(25): 21995 - 21998. [Abstract] [Full Text] [PDF]
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J. Gu, J. Milligan, and L. E. Huang Molecular Mechanism of Hypoxia-inducible Factor 1alpha -p300 Interaction. A LEUCINE-RICH INTERFACE REGULATED BY A SINGLE CYSTEINE J. Biol. Chem., January 26, 2001; 276(5): 3550 - 3554. [Abstract] [Full Text] [PDF]
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P. Gong, B. Hu, D. Stewart, M. Ellerbe, Y. G. Figueroa, V. Blank, B. S. Beckman, and J. Alam Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells. REGULATION BY Nrf2 AND MafG TRANSCRIPTION FACTORS J. Biol. Chem., July 13, 2001; 276(29): 27018 - 27025. [Abstract] [Full Text] [PDF]
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 A. Gorlach, I. Diebold, V. B. Schini-Kerth, U. Berchner-Pfannschmidt, U. Roth, R. P. Brandes, T. Kietzmann, and R. Busse Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells : Role of the p22phox-Containing NADPH Oxidase Circ. Res., July 6, 2001; 89(1): 47 - 54. [Abstract] [Full Text] [PDF]
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