QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kinnberg, K. Articles by Jespersen, A. Search for Related Content PubMed PubMed Citation Articles by Kinnberg, K. Articles by Jespersen, A. Social Bookmarking                         What's this?

Journal of Experimental Biology, Vol 203, Issue 2 171-181, Copyright © 2000 by Company of Biologists

JOURNAL ARTICLES

Effects of nonylphenol and 17beta-estradiol on vitellogenin synthesis and testis morphology in male platyfish Xiphophorus maculatus

K Kinnberg, B Korsgaard, P Bjerregaard and A Jespersen
Institute of Biology, Odense University, DK-5230 Odense M, Denmark and Institute of Zoology, University of Copenhagen, DK-2100 Copenhagen O, Denmark. kinnberg@biology.ou.dk

Nonylphenol has been found to exert estrogenic effects in fish and may influence the fertility of male fish. In the present study, the effects of nonylphenol and 17beta-estradiol on vitellogenin synthesis and testis morphology in platyfish Xiphophorus maculatus were investigated. Vitellogenin was observed in the plasma of all fish exposed to nonylphenol or 17beta-estradiol. Exposure to 17beta-estradiol resulted in a significant reduction in the gonadosomatic index. A tendency for a dose-dependent reduction in the gonadosomatic index in the nonylphenol exposed groups was observed. Histological examination revealed dose-dependent effects of nonylphenol on the testis structure. The testes of control fish contained numerous cysts with spermatogenetic cells. The testes of fish exposed to nonylphenol or 17beta-estradiol showed a decrease in the number of cysts concomitant with an increase in the amount of hypertrophied Sertoli cells present. Formation of spermatozeugmata is compulsory for this species, but free spermatozoa were observed in the efferent ducts of the treated fish. The study indicates that nonylphenol has estrogenic potency, and that both nonylphenol and 17beta-estradiol have marked effects on the testis morphology of X. maculatus. The ambient concentration of nonylphenol was measured by high pressure liquid chromatography during the experiment. The measurements revealed that the actual concentrations of nonylphenol in the water were about 30-40 % of the nominal concentrations.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				L M McClusky Stage and season effects on cell cycle and apoptotic activities of germ cells and Sertoli cells during spermatogenesis in the spiny dogfish (Squalus acanthias) Reproduction, January 1, 2005; 129(1): 89 - 102. [Abstract] [Full Text] [PDF]

				J. C. Wolf, D. R. Dietrich, U. Friederich, J. Caunter, and A. R. Brown Qualitative and Quantitative Histomorphologic Assessment of Fathead Minnow Pimephales promelas Gonads as an Endpoint for Evaluating Endocrine-Active Compounds: A Pilot Methodology Study Toxicol Pathol, August 1, 2004; 32(5): 600 - 612. [Abstract] [PDF]

				Y. Ushiba, Y. Takahara, and H. Ohta Sphingobium amiense sp. nov., a novel nonylphenol-degrading bacterium isolated from a river sediment Int J Syst Evol Microbiol, November 1, 2003; 53(6): 2045 - 2048. [Abstract] [Full Text] [PDF]