|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Journal of Experimental Biology, Vol 203, Issue 1 137-145, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
D Brown and S Breton
Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02129, USA. brown@receptor.mgh.harvard.edu
Many vertebrate transporting epithelia contain characteristic 'mitochondria-rich' cells that express high levels of a vacuolar proton-pumping ATPase (H(+)V-ATPase) on their plasma membrane and on intracellular vesicles. In the kidney cortex, A-cells and B-cells are involved in proton secretion and bicarbonate secretion, respectively, in the distal nephron and collecting duct. A-cells have an H(+)V-ATPase on their apical plasma membrane and on intracellular vesicles, whereas the cellular location of the H(+)V-ATPase can be apical, basolateral, bipolar or diffuse in B-cells. The rat epididymis and vas deferens also contain a distinct population of H(+)V-ATPase-rich epithelial cells. These cells are involved in generating a low luminal pH, which is involved in sperm maturation and in maintaining sperm in an immotile state during their passage through the epididymis and vas deferens. In both kidney and reproductive tract, H(+)V-ATPase-rich cells have a high rate of apical membrane recycling. H(+)V-ATPase molecules are transported between the cell surface and the cytoplasm in vesicles that have a well-defined 'coat' structure formed of the peripheral V(1) subunits of the H(+)V-ATPase. In addition, we propose that B-type intercalated cells have a transcytotic pathway that enables them to shuttle H(+)V-ATPase molecules from apical to basolateral plasma membrane domains. This hypothesis is supported by data showing that A-cells and B-cells have different intracellular trafficking pathways for LGP120, a lysosomal glycoprotein. LGP120 was found both on the basolateral plasma membrane and in lysosomes in B-cells, whereas no LGP120 was detectable in the plasma membrane of A-cells. We propose that the 'polarity reversal' of the H(+)V-ATPase in B-intercalated cells is mediated by a physiologically regulated transcytotic pathway that may be similar to that existing in some other cell types.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Allman, D. Johnson, and K. Nehrke Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans Am J Physiol Cell Physiol, November 1, 2009; 297(5): C1071 - C1081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Bartels, A. Schmiedl, J. Rosenbruch, and I. C. Potter Exposure of the gill epithelial cells of larval lampreys to an ion-deficient environment: a stereological study J. Electron Microsc. (Tokyo), August 1, 2009; 58(4): 253 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rein, M. Voss, W. Blenau, B. Walz, and O. Baumann Hormone-induced assembly and activation of V-ATPase in blowfly salivary glands is mediated by protein kinase A Am J Physiol Cell Physiol, January 1, 2008; 294(1): C56 - C65. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Paunescu, L. M. Russo, N. Da Silva, J. Kovacikova, N. Mohebbi, A. N. Van Hoek, M. McKee, C. A. Wagner, S. Breton, and D. Brown Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1915 - F1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M Hagedorn, R. W Carlin, and B. D Schultz Oxytocin and Vasopressin Stimulate Anion Secretion by Human and Porcine Vas Deferens Epithelia Biol Reprod, September 1, 2007; 77(3): 416 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Breton and D. Brown New insights into the regulation of V-ATPase-dependent proton secretion Am J Physiol Renal Physiol, January 1, 2007; 292(1): F1 - F10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ochotny, A. Van Vliet, N. Chan, Y. Yao, M. Morel, N. Kartner, H. P. von Schroeder, J. N. M. Heersche, and M. F. Manolson Effects of Human a3 and a4 Mutations That Result in Osteopetrosis and Distal Renal Tubular Acidosis on Yeast V-ATPase Expression and Activity J. Biol. Chem., September 8, 2006; 281(36): 26102 - 26111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Adams, K. R. Robinson, T. Fukumoto, S. Yuan, R. C. Albertson, P. Yelick, L. Kuo, M. McSweeney, and M. Levin Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates Development, May 1, 2006; 133(9): 1657 - 1671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Xu, R. T. Worrell, H. C. Li, S. L. Barone, S. Petrovic, H. Amlal, and M. Soleimani Chloride/Bicarbonate Exchanger SLC26A7 Is Localized in Endosomes in Medullary Collecting Duct Cells and Is Targeted to the Basolateral Membrane in Hypertonicity and Potassium Depletion J. Am. Soc. Nephrol., April 1, 2006; 17(4): 956 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pietrement, G-H. Sun-Wada, N. D. Silva, M. McKee, V. Marshansky, D. Brown, M. Futai, and S. Breton Distinct Expression Patterns of Different Subunit Isoforms of the V-ATPase in the Rat Epididymis Biol Reprod, January 1, 2006; 74(1): 185 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, T. Inoue, and M. Forgac Subunit a of the Yeast V-ATPase Participates in Binding of Bafilomycin J. Biol. Chem., December 9, 2005; 280(49): 40481 - 40488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Pastor-Soler, C. Pietrement, and S. Breton Role of Acid/Base Transporters in the Male Reproductive Tract and Potential Consequences of Their Malfunction Physiology, December 1, 2005; 20(6): 417 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Jouret, C. Auzanneau, H. Debaix, G.-H. S. Wada, C. Pretto, E. Marbaix, F. E. Karet, P. J. Courtoy, and O. Devuyst Ubiquitous and Kidney-Specific Subunits of Vacuolar H+-ATPase Are Differentially Expressed during Nephrogenesis J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3235 - 3246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Finberg, C. A. Wagner, M. A. Bailey, T. G. Paunescu, S. Breton, D. Brown, G. Giebisch, J. P. Geibel, and R. P. Lifton The B1-subunit of the H+ ATPase is required for maximal urinary acidification PNAS, September 20, 2005; 102(38): 13616 - 13621. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Chew, C. T. Okamoto, X. Chen, and R. Thomas Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G320 - G331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Inoue and M. Forgac Cysteine-mediated Cross-linking Indicates That Subunit C of the V-ATPase Is in Close Proximity to Subunits E and G of the V1 Domain and Subunit a of the V0 Domain J. Biol. Chem., July 29, 2005; 280(30): 27896 - 27903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Gatti, S. Metayer, M. Belghazi, F. Dacheux, and J.-L. Dacheux Identification, Proteomic Profiling, and Origin of Ram Epididymal Fluid Exosome-Like Vesicles Biol Reprod, June 1, 2005; 72(6): 1452 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Miller, P. Zhang, M. Smith, V. Beaulieu, T. G. Paunescu, D. Brown, S. Breton, and R. D. Nelson V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice Am J Physiol Cell Physiol, May 1, 2005; 288(5): C1134 - C1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Beaulieu, N. Da Silva, N. Pastor-Soler, C. R. Brown, P. J. S. Smith, D. Brown, and S. Breton Modulation of the Actin Cytoskeleton via Gelsolin Regulates Vacuolar H+-ATPase Recycling J. Biol. Chem., March 4, 2005; 280(9): 8452 - 8463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. I. Gorodeski, U. Hopfer, C. C. Liu, and E. Margles Estrogen Acidifies Vaginal pH by Up-Regulation of Proton Secretion via the Apical Membrane of Vaginal-Ectocervical Epithelial Cells Endocrinology, February 1, 2005; 146(2): 816 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Shao and M. Forgac Involvement of the Nonhomologous Region of Subunit A of the Yeast V-ATPase in Coupling and in Vivo Dissociation J. Biol. Chem., November 19, 2004; 279(47): 48663 - 48670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jones Sperm Survival Versus Degradation in the Mammalian Epididymis: A Hypothesis Biol Reprod, November 1, 2004; 71(5): 1405 - 1411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, T. Inoue, and M. Forgac TM2 but Not TM4 of Subunit c'' Interacts with TM7 of Subunit a of the Yeast V-ATPase as Defined by Disulfide-mediated Cross-linking J. Biol. Chem., October 22, 2004; 279(43): 44628 - 44638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Wagner, K. E. Finberg, S. Breton, V. Marshansky, D. Brown, and J. P. Geibel Renal Vacuolar H+-ATPase Physiol Rev, October 1, 2004; 84(4): 1263 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Bartels and I. C. Potter Cellular composition and ultrastructure of the gill epithelium of larval and adult lampreys: Implications for osmoregulation in fresh and seawater J. Exp. Biol., September 15, 2004; 207(20): 3447 - 3462. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Paunescu, N. D. Silva, V. Marshansky, M. McKee, S. Breton, and D. Brown Expression of the 56-kDa B2 subunit isoform of the vacuolar H+-ATPase in proton-secreting cells of the kidney and epididymis Am J Physiol Cell Physiol, July 1, 2004; 287(1): C149 - C162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Sennoune, K. Bakunts, G. M. Martinez, J. L. Chua-Tuan, Y. Kebir, M. N. Attaya, and R. Martinez-Zaguilan Vacuolar H+-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity Am J Physiol Cell Physiol, June 1, 2004; 286(6): C1443 - C1452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-Q. Sun, N. Balasubramaniyan, C.-J. Liu, M. Shahid, and F. J. Suchy Association of the 16-kDa Subunit c of Vacuolar Proton Pump with the Ileal Na+-dependent Bile Acid Transporter: PROTEIN-PROTEIN INTERACTION AND INTRACELLULAR TRAFFICKING J. Biol. Chem., April 16, 2004; 279(16): 16295 - 16300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ziegler, D. Weihrauch, M. Hagedorn, D. W. Towle, and R. Bleher Expression and polarity reversal of V-type H+-ATPase during the mineralization-demineralization cycle in Porcellio scaber sternal epithelial cells J. Exp. Biol., April 15, 2004; 207(10): 1749 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Hawkings, F. Galvez, and G. G. Goss Seawater acclimation causes independent alterations in Na+/K+- and H+-ATPase activity in isolated mitochondria-rich cell subtypes of the rainbow trout gill J. Exp. Biol., February 22, 2004; 207(6): 905 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishi, S. Kawasaki-Nishi, and M. Forgac Expression and Function of the Mouse V-ATPase d Subunit Isoforms J. Biol. Chem., November 21, 2003; 278(47): 46396 - 46402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawasaki-Nishi, T. Nishi, and M. Forgac Interacting Helical Surfaces of the Transmembrane Segments of Subunits a and c' of the Yeast V-ATPase Defined by Disulfide-mediated Cross-linking J. Biol. Chem., October 24, 2003; 278(43): 41908 - 41913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Shao, T. Nishi, S. Kawasaki-Nishi, and M. Forgac Mutational Analysis of the Non-homologous Region of Subunit A of the Yeast V-ATPase J. Biol. Chem., April 4, 2003; 278(15): 12985 - 12991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Katoh, S. Hyodo, and T. Kaneko Vacuolar-type proton pump in the basolateral plasma membrane energizes ion uptake in branchial mitochondria-rich cells of killifish Fundulus heteroclitus, adapted to a low ion environment J. Exp. Biol., March 1, 2003; 206(5): 793 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Carlin, J. H. Lee, D. C. Marcus, and B. D. Schultz Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia Biol Reprod, March 1, 2003; 68(3): 1027 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishi, S. Kawasaki-Nishi, and M. Forgac The First Putative Transmembrane Segment of Subunit c" (Vma16p) of the Yeast V-ATPase Is Not Necessary for Function J. Biol. Chem., February 14, 2003; 278(8): 5821 - 5827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Boesch, H. Niederstatter, and B. Pelster Localization of the vacuolar-type ATPase in swimbladder gas gland cells of the European eel (Anguilla anguilla) J. Exp. Biol., February 1, 2003; 206(3): 469 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Isnard-Bagnis, N. Da Silva, V. Beaulieu, A. S. L. Yu, D. Brown, and S. Breton Detection of ClC-3 and ClC-5 in epididymal epithelium: immunofluorescence and RT-PCR after LCM Am J Physiol Cell Physiol, January 1, 2003; 284(1): C220 - C232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Kalthoff, S. Groos, R. Kohl, S. Mahrhold, and E. J. Ungewickell Clint: A Novel Clathrin-binding ENTH-Domain Protein at the Golgi Mol. Biol. Cell, November 1, 2002; 13(11): 4060 - 4073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Fisher, N. Pastor-Soler, R. M. Sharpe, and S. Breton Modulation of the Onset of Postnatal Development of H+-ATPase-Rich Cells by Steroid Hormones in Rat Epididymis Biol Reprod, October 1, 2002; 67(4): 1106 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Carlin, R. R. Quesnell, L. Zheng, K. E. Mitchell, and B. D. Schultz Functional and molecular evidence for Na+-HCO3- cotransporter in porcine vas deferens epithelia Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1033 - C1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Kim, T.-H. Kwon, S. Frische, J. Kim, C. C. Tisher, K. M. Madsen, and S. Nielsen Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney Am J Physiol Renal Physiol, October 1, 2002; 283(4): F744 - F754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Granger, M. Marsolais, J. Burry, and R. Laprade V-type H+-ATPase in the human eccrine sweat duct: immunolocalization and functional demonstration Am J Physiol Cell Physiol, June 1, 2002; 282(6): C1454 - C1460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Christova, P. S. James, T. G. Cooper, and R. Jones Lipid Diffusion in the Plasma Membrane of Mouse Spermatozoa: Changes During Epididymal Maturation, Effects of pH, Osmotic Pressure, and Knockout of the c-ros Gene J Androl, May 1, 2002; 23(3): 384 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bebas, B. Cymborowski, and J. M. Giebultowicz Circadian rhythm of acidification in insect vas deferens regulated by rhythmic expression of vacuolar H+-ATPase J. Exp. Biol., January 1, 2002; 205(1): 37 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawasaki-Nishi, K. Bowers, T. Nishi, M. Forgac, and T. H. Stevens The Amino-terminal Domain of the Vacuolar Proton-translocating ATPase a Subunit Controls Targeting and in Vivo Dissociation, and the Carboxyl-terminal Domain Affects Coupling of Proton Transport and ATP Hydrolysis J. Biol. Chem., December 7, 2001; 276(50): 47411 - 47420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Smith, K. E. Finberg, C. A. Wagner, R. P. Lifton, M. A. J. Devonald, Y. Su, and F. E. Karet Molecular Cloning and Characterization of Atp6n1b. A NOVEL FOURTH MURINE VACUOLAR H+-ATPase a-SUBUNIT GENE J. Biol. Chem., November 2, 2001; 276(45): 42382 - 42388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oka, Y. Murata, M. Namba, T. Yoshimizu, T. Toyomura, A. Yamamoto, G.-H. Sun-Wada, N. Hamasaki, Y. Wada, and M. Futai a4, a Unique Kidney-specific Isoform of Mouse Vacuolar H+-ATPase Subunit a J. Biol. Chem., October 19, 2001; 276(43): 40050 - 40054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawasaki-Nishi, T. Nishi, and M. Forgac Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation PNAS, October 5, 2001; (2001) 221291798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Piermarini and D. H. Evans Immunochemical analysis of the vacuolar proton-ATPase B-subunit in the gills of a euryhaline stingray (Dasyatis sabina): effects of salinity and relation to Na+/K+-ATPase J. Exp. Biol., January 10, 2001; 204(19): 3251 - 3259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. S. Smith and J. Trimarchi Noninvasive measurement of hydrogen and potassium ion flux from single cells and epithelial structures Am J Physiol Cell Physiol, January 1, 2001; 280(1): C1 - C11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oka and M. Futai Requirement of V-ATPase for Ovulation and Embryogenesis in Caenorhabditis elegans J. Biol. Chem., September 15, 2000; 275(38): 29556 - 29561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Xu and M. Forgac Microtubules Are Involved in Glucose-dependent Dissociation of the Yeast Vacuolar [H+]-ATPase in Vivo J. Biol. Chem., June 29, 2001; 276(27): 24855 - 24861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Oka, T. Toyomura, K. Honjo, Y. Wada, and M. Futai Four Subunit a Isoforms of Caenorhabditis elegans Vacuolar H+-ATPase. CELL-SPECIFIC EXPRESSION DURING DEVELOPMENT J. Biol. Chem., August 24, 2001; 276(35): 33079 - 33085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nishi, S. Kawasaki-Nishi, and M. Forgac Expression and Localization of the Mouse Homologue of the Yeast V-ATPase 21-kDa Subunit c'' (Vma16p) J. Biol. Chem., August 31, 2001; 276(36): 34122 - 34130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arata, J. D. Baleja, and M. Forgac Cysteine-directed Cross-linking to Subunit B Suggests That Subunit E Forms Part of the Peripheral Stalk of the Vacuolar H+-ATPase J. Biol. Chem., January 25, 2002; 277(5): 3357 - 3363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawasaki-Nishi, T. Nishi, and M. Forgac Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation PNAS, October 23, 2001; 98(22): 12397 - 12402. [Abstract] [Full Text] [PDF]
|
|
