|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Journal of Experimental Biology, Vol 203, Issue 1 117-125, Copyright © 2000 by Company of Biologists
JOURNAL ARTICLES |
Y Moriyama, M Hayashi, H Yamada, S Yatsushiro, S Ishio and A Yamamoto
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. moriyama@pheasant.pharm.okayama-u.ac.jp.
Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H(+)-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate l-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use l-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  M. C. McGahan, J. Harned, M. Mukunnemkeril, M. Goralska, L. Fleisher, and J. B. Ferrell Iron alters glutamate secretion by regulating cytosolic aconitase activity Am J Physiol Cell Physiol, May 1, 2005; 288(5): C1117 - C1124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Braun, A. Wendt, B. Birnir, J. Broman, L. Eliasson, J. Galvanovskis, J. Gromada, H. Mulder, and P. Rorsman Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic {beta}-cells J. Gen. Physiol., February 23, 2004; 123(3): 191 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Moriyama and A. Yamamoto Glutamatergic Chemical Transmission: Look! Here, There, and Anywhere J. Biochem., February 1, 2004; 135(2): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hayashi, R. Morimoto, A. Yamamoto, and Y. Moriyama Expression and Localization of Vesicular Glutamate Transporters in Pancreatic Islets, Upper Gastrointestinal Tract, and Testis J. Histochem. Cytochem., October 1, 2003; 51(10): 1375 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Boesch, B. Eller, and B. Pelster Expression of two isoforms of the vacuolar-type ATPase subunit B in the zebrafish Danio rerio J. Exp. Biol., June 1, 2003; 206(11): 1907 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hayashi, H. Yamada, S. Uehara, R. Morimoto, A. Muroyama, S. Yatsushiro, J. Takeda, A. Yamamoto, and Y. Moriyama Secretory Granule-mediated Co-secretion of L-Glutamate and Glucagon Triggers Glutamatergic Signal Transmission in Islets of Langerhans J. Biol. Chem., January 10, 2003; 278(3): 1966 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tsuboi, Y. Kotani, K.'i. Ogawa, T. Hatanaka, S. Yatsushiro, M. Otsuka, and Y. Moriyama An Intramolecular Disulfide Bridge as a Catalytic Switch for Serotonin N-Acetyltransferase J. Biol. Chem., November 8, 2002; 277(46): 44229 - 44235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Chessler, W. T. Simonson, I. R. Sweet, and L. P. Hammerle Expression of the Vesicular Inhibitory Amino Acid Transporter in Pancreatic Islet Cells : Distribution of the Transporter Within Rat Islets Diabetes, June 1, 2002; 51(6): 1763 - 1771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Tong, R. Ouedraogo, and A. L. Kirchgessner Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets Am J Physiol Endocrinol Metab, June 1, 2002; 282(6): E1324 - E1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hayashi, M. Otsuka, R. Morimoto, S. Hirota, S. Yatsushiro, J. Takeda, A. Yamamoto, and Y. Moriyama Differentiation-associated Na+-dependent Inorganic Phosphate Cotransporter (DNPI) Is a Vesicular Glutamate Transporter in Endocrine Glutamatergic Systems J. Biol. Chem., November 9, 2001; 276(46): 43400 - 43406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamada, M. Otsuka, M. Hayashi, S. Nakatsuka, K. Hamaguchi, A. Yamamoto, and Y. Moriyama Ca2+-Dependent Exocytosis of L-Glutamate by {alpha}TC6, Clonal Mouse Pancreatic {alpha}-Cells Diabetes, May 1, 2001; 50(5): 1012 - 1020. [Abstract] [Full Text]
|
|
|
|
|
|
T. Oka and M. Futai Requirement of V-ATPase for Ovulation and Embryogenesis in Caenorhabditis elegans J. Biol. Chem., September 15, 2000; 275(38): 29556 - 29561. [Abstract] [Full Text] [PDF]
|
|
