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Journal of Experimental Biology, Vol 202, Issue 7 881-890, Copyright © 1999 by Company of Biologists
JOURNAL ARTICLES |
HA Shiels, EV Freund, AP Farrell and BA Block
Simon Fraser University, Department of Biological Sciences, Burnaby, British Columbia, Canada V5A 1S6 and Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA. hollys@sfu.ca.
We used an isometric muscle preparation to test the hypothesis that yellowfin tuna Thunnus albacares utilize the intracellular Ca2+ storage sites of the sarcoplasmic reticulum (SR) during routine contractions. Ryanodine (a blocker of SR Ca2+ release) reduced the force of contraction by approximately 50 % and the rates of contraction and relaxation by 60 % in yellowfin tuna atrium. High levels of adrenaline were unable to ameliorate the effects of ryanodine. We conclude that the SR is active in contributing Ca2+ to force development at physiological contraction frequencies. Further, we suggest that, by using intracellular Ca2+ cycling, the yellowfin tuna is able to increase the maximum contraction frequency of its cardiac muscle beyond that of most other fishes.
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A. M. Landeira-Fernandez, J. M. Morrissette, J. M. Blank, and B. A. Block Temperature dependence of the Ca2+-ATPase (SERCA2) in the ventricles of tuna and mackerel Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R398 - R404. [Abstract] [Full Text] [PDF]
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J. M. Blank, J. M. Morrissette, P. S. Davie, and B. A. Block Effects of temperature, epinephrine and Ca2+ on the hearts of yellowfin tuna (Thunnus albacares) J. Exp. Biol., July 1, 2002; 205(13): 1881 - 1888. [Abstract] [Full Text] [PDF]
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V. Tiitu and M. Vornanen Regulation of cardiac contractility in a cold stenothermal fish, the burbot Lota lota L. J. Exp. Biol., June 1, 2002; 205(11): 1597 - 1606. [Abstract] [Full Text] [PDF]
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H. Shiels, M Vornanen, and A. Farrell Temperature-dependence of L-type Ca(2+) channel current in atrial myocytes from rainbow trout J. Exp. Biol., January 9, 2000; 203(18): 2771 - 2780. [Abstract] [PDF]
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