|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Journal of Experimental Biology, Vol 201, Issue 8 1197-1201, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
HF Bunn, J Gu, LE Huang, JW Park and H Zhu
Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. bunn@calvin.bwh.harvard.edu
The physiological regulation of the red cell mass depends upon enhanced transcription of the erythropoietin (Epo) gene in response to hypoxia. Studies of Epo gene expression have been useful in investigating the mechanism by which cells and tissues sense hypoxia and respond with biologically appropriate alterations in gene expression. It is likely that oxygen sensing involves a heme protein in which cobalt and nickel can substitute for iron in the porphyrin ring. Indirect evidence suggests that the sensor is present in all cells and is a multi-subunit assembly containing an NAD(P)H oxidase capable of generating peroxide and reactive oxygen intermediates, which serve as signaling molecules. The up-regulation of Epo gene transcription by hypoxia is mediated by at least two known DNA-binding transcription factors, hypoxia-inducible factor 1 (HIF-1) and hepatic nuclear factor 4 (HNF-4), which bind to cognate response elements in a critical 3' enhancer approximately 50 bp in length. HIF-1 binding is induced by hypoxia as well as by cobalt. The activation of HIF-1 by hypoxia depends upon the selective protection of its alpha subunit from ubiquitin-dependent proteolysis by means of a mechanism that involves redox chemistry and perhaps phosphorylation. HNF-4 is an orphan nuclear receptor that is constitutively expressed in kidney and liver and which cooperates with HIF-1 to give maximal hypoxic induction. In hypoxic cells, p300 or a related family member forms a macromolecular assembly with HIF-1 and HNF-4, enabling transduction from the Epo 3' enhancer to the apparatus on the promoter responsible for the initiation of transcription.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Eckle, D. Kohler, R. Lehmann, K. C. El Kasmi, and H. K. Eltzschig Hypoxia-Inducible Factor-1 Is Central to Cardioprotection: A New Paradigm for Ischemic Preconditioning Circulation, July 8, 2008; 118(2): 166 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M Abu El-Asrar, L. Missotten, and K. Geboes Expression of hypoxia-inducible factor-1{alpha} and the protein products of its target genes in diabetic fibrovascular epiretinal membranes Br J Ophthalmol, June 1, 2007; 91(6): 822 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Leosco, G. Rengo, G. Iaccarino, E. Sanzari, L. Golino, G. D. Lisa, C. Zincarelli, F. Fortunato, M. Ciccarelli, V. Cimini, et al. Prior Exercise Improves Age-Dependent Vascular Endothelial Growth Factor Downregulation and Angiogenesis Responses to Hind-Limb Ischemia in Old Rats J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2007; 62(5): 471 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Chavez, O. Baranova, J. Lin, and P. Pichiule The Transcriptional Activator Hypoxia Inducible Factor 2 (HIF-2/EPAS-1) Regulates the Oxygen-Dependent Expression of Erythropoietin in Cortical Astrocytes J. Neurosci., September 13, 2006; 26(37): 9471 - 9481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. He, B. Dinger, K. Sanders, J. Hoidal, A. Obeso, L. Stensaas, S. Fidone, and C. Gonzalez Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L916 - L924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Kumar, G. Acs, D. Fang, M. Herlyn, D. E. Elder, and X. Xu Functional Erythropoietin Autocrine Loop in Melanoma Am. J. Pathol., March 1, 2005; 166(3): 823 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-L. Paul, A. C. Schuerger, M. P. Popp, J. T. Richards, M. S. Manak, and R. J. Ferl Hypobaric Biology: Arabidopsis Gene Expression at Low Atmospheric Pressure Plant Physiology, January 1, 2004; 134(1): 215 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Galban, J. L. Martindale, K. Mazan-Mamczarz, I. Lopez de Silanes, J. Fan, W. Wang, J. Decker, and M. Gorospe Influence of the RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells Mol. Cell. Biol., October 15, 2003; 23(20): 7083 - 7095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Sanders, K. M. Sundar, L. He, B. Dinger, S. Fidone, and J. R. Hoidal Role of components of the phagocytic NADPH oxidase in oxygen sensing J Appl Physiol, October 1, 2002; 93(4): 1357 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Stolze, U. Berchner-Pfannschmidt, P. Freitag, C. Wotzlaw, J. Rossler, S. Frede, H. Acker, and J. Fandrey Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells Blood, September 18, 2002; 100(7): 2623 - 2628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Boutilier Mechanisms of cell survival in hypoxia and hypothermia J. Exp. Biol., March 11, 2002; 204(18): 3171 - 3181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Andrew, L. R. Klei, and A. Barchowsky Nickel requires hypoxia-inducible factor-1{alpha}, not redox signaling, to induce plasminogen activator inhibitor-1 Am J Physiol Lung Cell Mol Physiol, September 1, 2001; 281(3): L607 - L615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Makita, G. Hernandez-Hoyos, T. H.-P. Chen, H. Wu, E. V. Rothenberg, and H. M. Sucov A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4 Genes & Dev., April 1, 2001; 15(7): 889 - 901. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Vincent, K.-G. Shyu, Y. Luo, M. Magner, R. A. Tio, C. Jiang, M. A. Goldberg, G. Y. Akita, R. J. Gregory, and J. M. Isner Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1{alpha}/VP16 Hybrid Transcription Factor Circulation, October 31, 2000; 102(18): 2255 - 2261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Corwin Understanding Cytokines Part I: Physiology and Mechanism of Action Biol Res Nurs, July 1, 2000; 2(1): 30 - 40. [Abstract] [PDF]
|
|
|
|
|
|
W. Van Voorhies and S Ward Broad oxygen tolerance in the nematode Caenorhabditis elegans J. Exp. Biol., January 8, 2000; 203(16): 2467 - 2478. [Abstract] [PDF]
|
|
|
|
|
|
D. W. Russell and M. A. Kay Adeno-Associated Virus Vectors and Hematology Blood, August 1, 1999; 94(3): 864 - 874. [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Taylor and I. B. Zhulin PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light Microbiol. Mol. Biol. Rev., June 1, 1999; 63(2): 479 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Kwast, P. V. Burke, B. T. Staahl, and R. O. Poyton Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes PNAS, May 11, 1999; 96(10): 5446 - 5451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Laderoute, H. L. Mendonca, J. M. Calaoagan, A. M. Knapp, A. J. Giaccia, and P. J. S. Stork Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression Is Induced by Low Oxygen Conditions Found in Solid Tumor Microenvironments. A CANDIDATE MKP FOR THE INACTIVATION OF HYPOXIA-INDUCIBLE STRESS-ACTIVATED PROTEIN KINASE/c-Jun N-TERMINAL PROTEIN KINASE ACTIVITY J. Biol. Chem., April 30, 1999; 274(18): 12890 - 12897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ghilardi, A. Wiestner, and R. C. Skoda Thrombopoietin Production Is Inhibited by a Translational Mechanism Blood, December 1, 1998; 92(11): 4023 - 4030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Lee and P. M. Corry Metabolic Oxidative Stress-induced HSP70 Gene Expression Is Mediated through SAPK Pathway. ROLE OF Bcl-2 AND c-Jun NH2-TERMINAL KINASE J. Biol. Chem., November 6, 1998; 273(45): 29857 - 29863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rivard, L. Berthou-Soulie, N. Principe, M. Kearney, C. Curry, D. Branellec, G. L. Semenza, and J. M. Isner Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity J. Biol. Chem., September 15, 2000; 275(38): 29643 - 29647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shiose, J. Kuroda, K. Tsuruya, M. Hirai, H. Hirakata, S. Naito, M. Hattori, Y. Sakaki, and H. Sumimoto A Novel Superoxide-producing NAD(P)H Oxidase in Kidney J. Biol. Chem., January 5, 2001; 276(2): 1417 - 1423. [Abstract] [Full Text] [PDF]
|
|
