spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Forsbach, A.
Right arrow Articles by Heinlein, U. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Forsbach, A.
Right arrow Articles by Heinlein, U. A.

Journal of Experimental Biology, Vol 201, Issue 6 861-867, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Intratesticular distribution of cyritestin, a protein involved in gamete interaction

A Forsbach and UA Heinlein
Intitut fur Genetik, Heinrich-Heine-Universitat, Dusseldorf, Germany.

Cyritestin, a member of the ADAM family of proteins, has been shown to be involved in the interaction between sperm and egg during fertilization. The protein is a transmembrane protein associated with the sperm acrosome. In the present study, electron microscopy was used to trace the distribution of the cyritestin molecule in intratesticular germ cells, particularly in haploid round spermatids where the acrosomal structure is differentiating. Our results indicate that cyritestin is transported to the forming acrosomal vesicle through the Golgi apparatus to become part of the acrosomal membrane. Differential staining with antibodies recognizing either the metalloprotease-like domain or the cytoplasmic domain of cyritestin indicates that processing of the molecule leading to the loss of the pro- and metalloproteinase-like domains begins during germ cell stage 6 and is completed before stage 15.


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
M. Klissenbauer, S. Winters, U. A. O. Heinlein, and T. Lisowsky
Accumulation of the mitochondrial form of the sulphydryl oxidase Erv1p/Alrp during the early stages of spermatogenesis
J. Exp. Biol., July 15, 2002; 205(14): 1979 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
R. Shamsadin, I. M. Adham, K. Nayernia, U. A.O. Heinlein, H. Oberwinkler, and W. Engel
Male Mice Deficient for Germ-Cell Cyritestin Are Infertile
Biol Reprod, December 1, 1999; 61(6): 1445 - 1451.
[Abstract] [Full Text]


© The Company of Biologists Ltd 1998