spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thi, A. D.
Right arrow Articles by Rouget, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thi, A. D.
Right arrow Articles by Rouget, P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal of Experimental Biology, Vol 201, Issue 6 851-860, Copyright © 1998 by Company of Biologists

JOURNAL ARTICLES

Proliferation and differentiation properties of permanent Schwann cell lines immortalized with a temperature-sensitive oncogene

AD Thi, C Evrard and P Rouget
Laboratorie Biologie Moleculaire et Differenciation, Unite de Genetique Oncologique, CNRS-URA 1967, Insitut Gustave Roussy, Villejuif, France.

Permanent Schwann cells lines have been established in culture after stable transfection of newborn rat Schwann cells with the pJC-SVLTtsA vector, expressing a thermosensitive oncogene driven by the early promoter-enhancer region of the gliotropic GS/B variant of the papovavirus JC. The proliferation and differentiation of two clonal cell lines have been studied. The cells of these lines display the morphology of primary Schwann cells and express Schwann cell differentiation markers such as the S-100 protein, laminin, the low-affinity receptor to nerve growth factor and the glial fibrillary acidic protein. One of the lines is able to differentiate further. Indeed, in the presence of dorsal root ganglion neurones, the cells synthesize the myelin Po protein and are capable of some myelination, although to a lesser extent than secondary Schwann cells.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
G. Groyer, B. Eychenne, C. Girard, K. Rajkowski, M. Schumacher, and F. Cadepond
Expression and Functional State of the Corticosteroid Receptors and 11{beta}-Hydroxysteroid Dehydrogenase Type 2 in Schwann Cells
Endocrinology, September 1, 2006; 147(9): 4339 - 4350.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Maggi, F. Pimpinelli, L. Molteni, M. Milani, L. Martini, and F. Piva
Immortalized Luteinizing Hormone-Releasing Hormone Neurons Show a Different Migratory Activity in Vitro
Endocrinology, June 1, 2000; 141(6): 2105 - 2112.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
R. Cohen, R Mckay, and G Almazan
Cyclic AMP regulates PDGF-stimulated signal transduction and differentiation of an immortalized optic-nerve-derived cell line
J. Exp. Biol., January 2, 1999; 202(4): 461 - 473.
[Abstract] [PDF]


© The Company of Biologists Ltd 1998