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Journal of Experimental Biology, Vol 201, Issue 14 2091-2102, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
DB Mount, E Delpire, G Gamba, AE Hall, E Poch, RS Hoover and SC Hebert
Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Electroneutral cation-chloride cotransporters are widely expressed and perform a variety of physiological roles. A novel gene family of five members, encompassing a Na+-Cl- transporter, two Na+-K+-2Cl- transporters and two K+-Cl- cotransporters, encodes these membrane proteins; homologous genes have also been identified in a prokaryote and a number of lower eukaryotes. The cotransporter proteins share a common predicted membrane topology, with twelve putative transmembrane segments flanked by long hydrophilic N- and C-terminal cytoplasmic domains. The molecular identification of these transporters has had a significant impact on the study of their function, regulation and pathophysiology.
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