|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Journal of Experimental Biology, Vol 201, Issue 13 2081-2090, Copyright © 1998 by Company of Biologists
JOURNAL ARTICLES |
KA Hammond and DN Janes
Department of Biology, University of California, Riverside, CA 92521, USA. khammond@ucrac1.ucr.edu
In endothermic vertebrates, long-term increases in metabolic energy demand are often associated with increases in food intake and accompanied by increases in organ mass. Wide-scale increases in organ mass have often been attributed to a metabolic response to increased energy intake and utilization. On a constant diet, however, increased food intake is also associated with increased protein intake. We hypothesized that, while increased food intake itself may be responsible for increases in digestive tract mass, the consequent increased protein intake would be the factor responsible for increased kidney mass and function. Thus, we exposed male and female mice to diets differing in protein level (7 %, 15 % or 46 % casein by mass) at different acclimation temperatures (5 degrees C or 23 degrees C). Within an acclimation temperature, food intake rate remained constant over the entire range of dietary protein level, and protein intake rate increased as dietary content increased. The mice in the cold-acclimation group increased food intake rate by 48-120 % over those in the warm-acclimation group. Liver, kidney and stomach mass increased with protein intake rate, while digestive tract and other vital organ masses increased only in response to increased energy intake rate. Blood urea nitrogen levels increased with protein intake rate. Glomerular filtration rates increased with increases in dietary protein level in male mice but not female mice. Finally nitrogen filtration rate increased with protein intake rate for mice on the high-protein diet. We suggest that it is primarily the increased protein intake rate rather than the increased food intake rate that results in the changes in kidney and liver mass and kidney function observed to occur in situations of high energy demand.
This article has been cited by other articles:
|
|
 |
|
  G. Cherala, B. H. Shapiro, and A. P. D'mello Two Low Protein Diets Differentially Affect Food Consumption and Reproductive Performance in Pregnant and Lactating Rats and Long-Term Growth in Their Offspring J. Nutr., November 1, 2006; 136(11): 2827 - 2833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lacroix, C. Gaudichon, A. Martin, C. Morens, V. Mathe, D. Tome, and J.-F. Huneau A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R934 - R942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Qi, I. Whitt, A. Mehta, J. Jin, M. Zhao, R. C. Harris, A. B. Fogo, and M. D. Breyer Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance Am J Physiol Renal Physiol, March 1, 2004; 286(3): F590 - F596. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. R. Speakman, T. Ergon, R. Cavanagh, K. Reid, D. M. Scantlebury, and X. Lambin Resting and daily energy expenditures of free-living field voles are positively correlated but reflect extrinsic rather than intrinsic effects PNAS, November 25, 2003; 100(24): 14057 - 14062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Lopez-Calleja, M. J. Fernandez, and F. Bozinovic The integration of energy and nitrogen balance in the hummingbird Sephanoides sephaniodes J. Exp. Biol., October 1, 2003; 206(19): 3349 - 3359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Kristan Maternal and direct effects of the intestinal nematode Heligmosomoides polygyrus on offspring growth and susceptibility to infection J. Exp. Biol., December 15, 2002; 205(24): 3967 - 3977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Nespolo, L. D. Bacigalupe, P. Sabat, and F. Bozinovic Interplay among energy metabolism, organ mass and digestive enzyme activity in the mouse-opossum Thylamys elegans: the role of thermal acclimation J. Exp. Biol., September 1, 2002; 205(17): 2697 - 2703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Jean, S. Rome, V. Mathé, J.-F. Huneau, N. Aattouri, G. Fromentin, C. L. Achagiotis, and D. Tomé Metabolic Evidence for Adaptation to a High Protein Diet in Rats J. Nutr., January 1, 2001; 131(1): 91 - 98. [Abstract] [Full Text]
|
|
