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Journal of Experimental Biology, Vol 200, Issue 6 1025-1030, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Possible mediation of G-proteins in cold-sensory transduction in

Y Nakaoka, T Tanaka, T Kuriu and T Murata

The possible involvement of G-proteins in cold-sensory transduction was examined using voltage-clamped Paramecium multimicronucleatum into which non-hydrolyzable guanosine nucleotide analogues had been applied intracellularly. Guanosine-5'-O-3-thiotriphosphate, guanosine-5'-O-2-thiodiphosphate and aluminium fluoride all reduced the transient inward current in response to cooling, suggesting the possibility that G-proteins mediate cold-sensory transduction. Internal application of a Ca2+ chelator, EGTA, also reduced the current response. In addition to their effect on reducing the cold-sensory response, application of these chemicals modulated both the resting potential and the membrane conductance. Possible correlations between G-protein activity and the regulation of intracellular Ca2+ levels are discussed.
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© The Company of Biologists Ltd 1997