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Journal of Experimental Biology, Vol 200, Issue 11 1571-1586, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Characterization of voltage- and Ca(2+)-activated K+ channels in squid olfactory receptor neurons

MT Lucero and N Chen
Department of Physiology, School of Medicine, University of Utah, Salt Lake City 84108, USA.

We performed whole-cell voltage-clamp experiments on isolated olfactory neurons from the squid Lolliguncula brevis. Total outward currents were composed of three identifiable K+ currents: a delayed rectifier K+ current that showed slow inactivation and was sensitive to 5 mmol l-1 tetraethylammonium; a rapidly inactivating, 4-aminopyridine (4-AP)-sensitive, A-type K+ current and a Ca(2+)-sensitive K+ current that was blocked by 200 nmol l-1 charybdotoxin and 10 mmol l-1 Cd2+ but was insensitive to apamin. The proportion of each current type varied from cell to cell, suggesting that responses to a given odorant would depend of the complement of channels present. The kinetics of the K+ currents were affected by temperature, with Q10 values ranging from 2 to 6. The identification and characterization of these K+ currents will greatly aid our understanding of action potential generation in these cells and will facilitate modelling of how odor responses are transduced and coded in squid olfactory receptor neurons.


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© The Company of Biologists Ltd 1997