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Journal of Experimental Biology, Vol 200, Issue 1 1-8, Copyright © 1997 by Company of Biologists

JOURNAL ARTICLES

Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases

S Drose and K Altendorf
Universitat Osnabruck, Fachbereich Biologie/Chemie, Germany.

Bafilomycins and concanamycins, two groups of the plecomacrolide-defined class of macrolide antibiotics, have recently been recognized as important tools for studying the physiological role of vacuolar-type, proton-translocating ATPases (V-ATPases) and ATPases with phosphorylated states (P-ATPases) in animal and plant cells as well as in yeast, fungi and bacteria. The following review will give an account of the classification and function of these antibiotics.


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