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Journal of Experimental Biology, Vol 198, Issue 4 889-894, Copyright © 1995 by Company of Biologists

JOURNAL ARTICLES

A GABAB receptor on an identified insect motor neurone

D Bai and D Sattelle

The vertebrate GABAB receptor (GABABR) agonists 3-aminopropylphosphonous acid (3-APPA), SK&F97541 and 3-aminopropylphosphonic acid (3-APA) are able to induce a hyperpolarization on the cell body of motor neurone Df in the metathoracic ganglion of the cockroach (Periplaneta americana), although the classic vertebrate GABABR agonist l-baclofen fails to induce any responses on the same neurone. Consistent with the findings on vertebrate GABABRs, the 3-APPA-induced responses on Df were also insensitive to the GABAAR antagonists bicuculline and picrotoxin. However, the GABABR antagonists saclofen and CGP35348 also failed to block this GABAB-like response. These results indicate a novel pharmacology for the GABAB-like receptors on the Df neurone. The reversal potential indicates that these GABAB-like receptors may be coupled to K+ channels.


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© The Company of Biologists Ltd 1995