|
| |
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
Journal of Experimental Biology, Vol 184, Issue 1 183-196, Copyright © 1993 by Company of Biologists
JOURNAL ARTICLES |
TR Cheek and VA Barry
AFRC Laboratory of Molecular Signalling, Department of Zoology, Cambridge, UK.
Secretion of vesicular contents by exocytosis is a common feature of neuroendocrine secretory cells such as adrenal chromaffin cells and PC12 cells. Although it is clear that in these cells an elevation in intracellular calcium concentration, [Ca2+]i, is the triggering event that induces secretion, recent studies using video-imaging, patch-clamp and flash photolysis techniques have all indicated that the Ca2+ signal that triggers secretion is in fact very complex, with the subcellular distribution of Ca2+ being of particular importance along with the magnitude of the rise. It has become evident that Ca2+ signals with different spatial profiles can be triggered in the same cell by a given stimulus, depending upon the nature of the Ca2+ signalling pathway activated, and that this ability to be able to vary the method of delivery of Ca2+ into the cell is important physiologically, because it provides a means of obtaining differential activation of Ca(2+)-dependent processes.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Hu, E. A. Oboukhova, S. Kumar, M. Sturek, and A. G. Obukhov Canonical Transient Receptor Potential Channels Expression Is Elevated in a Porcine Model of Metabolic Syndrome Mol. Endocrinol., May 1, 2009; 23(5): 689 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Garcia, A. M. Garcia-De-Diego, L. Gandia, R. Borges, and J. Garcia-Sancho Calcium signaling and exocytosis in adrenal chromaffin cells. Physiol Rev, October 1, 2006; 86(4): 1093 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, and T. Dohi Pituitary Adenylate Cyclase-Activating Polypeptide Induces a Sustained Increase in Intracellular Free Ca2+ Concentration and Catecholamine Release by Activating Ca2+ Influx via Receptor-Stimulated Ca2+ Entry, Independent of Store-Operated Ca2+ Channels, and Voltage-Dependent Ca2+ Channels in Bovine Adrenal Medullary Chromaffin Cells J. Pharmacol. Exp. Ther., September 1, 2002; 302(3): 972 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Thuerauf, H. Hoover, J. Meller, J. Hernandez, L. Su, C. Andrews, W. H. Dillmann, P. M. McDonough, and C. C. Glembotski Sarco/endoplasmic Reticulum Calcium ATPase-2 Expression Is Regulated by ATF6 during the Endoplasmic Reticulum Stress Response. INTRACELLULAR SIGNALING OF CALCIUM STRESS IN A CARDIAC MYOCYTE MODEL SYSTEM J. Biol. Chem., December 14, 2001; 276(51): 48309 - 48317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Herring, I. M. Slotin, J. M. Baltz, and C. E. Morris Neuronal swelling and surface area regulation: elevated intracellular calcium is not a requirement Am J Physiol Cell Physiol, January 1, 1998; 274(1): C272 - C281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Klauke and H Plattner Imaging of Ca2+ transients induced in Paramecium cells by a polyamine secretagogue J. Cell Sci., January 4, 1997; 110(8): 975 - 983. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Mahata, S. K. Mahata, R. J. Parmer, and D. T. O'Connor Vesicular Monoamine Transport Inhibitors: Novel Action at Calcium Channels to Prevent Catecholamine Secretion Hypertension, September 1, 1996; 28(3): 414 - 420. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Finnegan and R. M. Wightman Correlation of Real-time Catecholamine Release and Cytosolic Ca[IMAGE] at Single Bovine Chromaffin Cells J. Biol. Chem., March 10, 1995; 270(10): 5353 - 5359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Barry and T. Cheek Extracellular ATP triggers two functionally distinct calcium signalling pathways in PC12 cells J. Cell Sci., January 2, 1994; 107(2): 451 - 462. [Abstract] [PDF]
|
|
