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Journal of Experimental Biology, Vol 173, Issue 1 251-260, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

The effect of a glutamate uptake inhibitor on axon-Schwann cell signalling in the squid giant nerve fibre

PD Evans, V Reale, RM Merzon and J Villegas
Department of Zoology, University of Cambridge, United Kingdom.

The glutamate uptake blocker p-chloromercuriphenylsulphonic acid (PCMS) (100 mumol l-1) does not block any of the membrane potential changes induced by the application of L-glutamate to the adaxonal Schwann cells of the giant axon of the tropical squid Sepioteuthis sepioidea. This indicates that these potential changes are not due to the activation of an electrogenic glutamate uptake system and supports the idea that they are due to the activation of specific glutamate receptors. The presence of PCMS (100 mumol l-1) reduces the activity of the glutamate uptake system sufficiently for the extracellular level of axonally released glutamate to exceed the threshold for the activation of the NMDA-type glutamate receptors in this preparation.




© The Company of Biologists Ltd 1992