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Journal of Experimental Biology, Vol 172, Issue 1 179-192, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

V-ATPases in phagocytic cells

S Grinstein, A Nanda, G Lukacs and O Rotstein
Division of Cell Biology Hospital for Sick Children, Toronto, Canada.

V-ATPases in phagocytic cells are known to mediate the acidification of most intracellular organelles. Proton-pump-mediated acidification of these organellar compartments is vital to numerous cell processes, including receptor recycling, protein processing and sorting and microbial degradation. Recent studies have suggested a role for V-ATPases in cytoplasmic pH homeostasis. The present discussion will review the current knowledge regarding the presence of V-ATPases in both the plasmalemmal and organellar membranes of phagocytic cells, the regulation of proton pump activity in these locations and the functional significance of pump-mediated proton translocation.


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© The Company of Biologists Ltd 1992