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Journal of Experimental Biology, Vol 171, Issue 1 329-347, Copyright © 1992 by Company of Biologists
JOURNAL ARTICLES |
J Schmidt and RL Calabrese
Department of Biology, Emory University, Atlanta, GA 30322.
1. In the leech, synaptic transmission between heart interneurons (HN cells) and between HN cells and heart motor neurons (HE cells) is blocked by bicuculline methiodide. 2. Gamma-aminobutyric acid, when applied focally onto the somata of HN cells or when added to the superfusate, has no effect on the membrane potential of HN cells. 3. Both acetylcholine (ACh) and the ACh agonist carbachol hyperpolarize HN cells and HE cells when applied focally onto their somata or into the neuropil or when added to the superfusate. 4. Inhibitory postsynaptic-potential-like responses elicited by focal application of carbachol onto the somata of HN cells and HE cells are blocked by bicuculline methiodide and are reversed when Cl- is injected into the cells. 5. Focal application of carbachol onto the somata of HN cells and HE cells increases membrane conductance. 6. The results indicate that HN cells use ACh as an inhibitory transmitter, that the postsynaptic receptors for ACh are blocked by bicuculline methiodide and that inhibition of HN cells and HE cells is mediated by an increased Cl- conductance.
This article has been cited by other articles:
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A.-E. Tobin and R. L. Calabrese Endogenous and Half-Center Bursting in Morphologically Inspired Models of Leech Heart Interneurons J Neurophysiol, October 1, 2006; 96(4): 2089 - 2106. [Abstract] [Full Text] [PDF]
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A.-E. Tobin, S. D. Van Hooser, and R. L. Calabrese Creation and Reduction of a Morphologically Detailed Model of a Leech Heart Interneuron J Neurophysiol, October 1, 2006; 96(4): 2107 - 2120. [Abstract] [Full Text] [PDF]
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G. S. Cymbalyuk, Q. Gaudry, M. A. Masino, and R. L. Calabrese Bursting in Leech Heart Interneurons: Cell-Autonomous and Network-Based Mechanisms J. Neurosci., December 15, 2002; 22(24): 10580 - 10592. [Abstract] [Full Text] [PDF]
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A. Wenning, C. F. J. Erxleben, and R. L. Calabrese Indirectly Gated Cl--Dependent Cl- Channels Sense Physiological Changes of Extracellular Chloride in the Leech J Neurophysiol, October 1, 2001; 86(4): 1826 - 1838. [Abstract] [Full Text] [PDF]
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O. H. Olsen and R. L. Calabrese Activation of Intrinsic and Synaptic Currents in Leech Heart Interneurons by Realistic Waveforms J. Neurosci., August 15, 1996; 16(16): 4958 - 4970. [Abstract] [Full Text] [PDF]
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