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Journal of Experimental Biology, Vol 165, Issue 1 61-71, Copyright © 1992 by Company of Biologists

JOURNAL ARTICLES

Characterization of a vasodilator from the salivary glands of the yellow fever mosquito Aedes aegypti

JM Ribeiro
Department of Entomology, University of Arizona, Tucson 85721.

Salivary gland homogenates and oil-induced saliva of the mosquito Aedes aegypti dilate the rabbit aortic ring and contract the guinea pig ileum. The vasodilatory activity is endothelium-dependent, heat-stable, sensitive to both trypsin and chymotrypsin treatments, and both smooth muscle activities cross-desensitize to the tachykinin peptide substance P. Both bioactivities co-elute when salivary gland homogenates are fractionated by reversed-phase HPLC. Molecular sieving chromatography indicates a relative molecular mass of 1400. A monoclonal antibody specific to the carboxy terminal region of tachykinins reacts with material in the posterior part of the central lobe of paraformaldehyde-fixed salivary glands. The presence of a vasodilatory peptide of the tachykinin family in the salivary glands of A. aegypti is proposed and its role in blood feeding is discussed.


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© The Company of Biologists Ltd 1992